文献类型：期刊文献

英文题名：Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury

作者：Li, Yangyang[1];Zhang, Yiming[1];Wei, Kongxi[1];He, Jinpeng[2,3];Ding, Nan[2,3];Hua, Junrui[2,3];Zhou, Ting[1];Niu, Fan[1];Zhou, Gucheng[1];Shi, Tongfan[1];Zhang, Liying[1,4];Liu, Yongqi[1,5]

第一作者：李圆圆;李燕云;李永玉

通信作者：Zhang, LY[1];Liu, YQ[1];Zhang, LY[2];Liu, YQ[3]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China;[3]Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China;[4]Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China;[5]Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]corresponding author), Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China;[3]corresponding author), Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2021

卷号：11

外文期刊名：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85111145570);WOS:【SCI-EXPANDED(收录号:WOS:000677391500001)】；

基金：This project was supported by the National Natural Science Foundation of China (grant numbers 81973595, 82004094), China Postdoctoral Science Foundation Project (grant numbers 2021M693794), The Open Fund Project of Key Laboratory of Dunhuang Medicine and Translational Education Ministry (grant numbers DHYX19-13).

语种：英文

外文关键词：radiotherapy; gut microbiota; dysbiosis; metabolites; SCFAs; radiation-induced intestinal injury

摘要：Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbiota can always be affected by various factors and among them, it is radiotherapy that results in gut microbiota (12)dysbiosis and it is often embodied in a decrease in the abundance and diversity of gut microbiota, an increase in harmful bacteria and a decrease in beneficial bacteria, thereby affecting many disease states, especially intestine diseases. Furthermore, gut microbiota can produce a variety of metabolites, among which short-chain fatty acids (SCFAs) are one of the most abundant and important metabolites. More importantly, SCFAs can be identified as second messengers to promote signal transduction and affect the occurrence and development of diseases. Radiotherapy can lead to the alterations of SCFAs-producing bacteria and cause changes in SCFAs, which is associated with a variety of diseases such as radiation-induced intestinal injury. However, the specific mechanism of its occurrence is not yet clear. Therefore, this review intends to emphasize the alterations of gut microbiota after radiotherapy and highlight the alterations of SCFAs-producing bacteria and SCFAs to explore the mechanisms of radiation-induced intestinal injury from the perspective of gut microbiota and its metabolite SCFAs.