文献类型：期刊文献

英文题名：Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation

作者：Zeng, Zhaoyang[1];Zhang, Hua[1];Wang, Xin[2];Liu, Kai[1];Li, Tian[1];Sun, Shaobo[1];Li, Hailong[1]

第一作者：曾昭洋

通信作者：Zeng, ZY[1]

机构：[1]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 35 DongGang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Orthoped, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 35 DongGang West Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2018

卷号：15

期号：2

起止页码：2679

外文期刊名：ONCOLOGY LETTERS

收录：;Scopus(收录号：2-s2.0-85038437291);WOS:【SCI-EXPANDED(收录号:WOS:000426145100091)】；

语种：英文

外文关键词：salvianolic Acid B; osteosarcoma; tumor protein 38; reactive oxygen species

摘要：The present study aimed to investigate the potential anticancer effect and mechanisms of salvianolic acid B on osteosarcoma. Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. Additionally, Salvianolic acid B also increased the level of reactive oxygen species (ROS) generation in the MG63 cells. The silencing of p38 expression inhibited the anticancer effect of salvianolic acid B on the levels of cell proliferation, p-p53 protein expression and ROS generation level in the MG63 cells. All these data supported the hypothesis that the anticancer effect of salvianolic acid B includes the suppression of cell proliferation and induces apoptosis in MG63 cells, and that p38 is important in the anticancer effect of salvianolic acid B on osteosarcoma cells due to the direct regulation of ROS generation. These data suggest that salvianolic acid B is important in the proliferation of osteosarcoma cells due to the direct regulation of p38-mediated ROS signaling.