文献类型：期刊文献

英文题名：Ciprofol versus propofol for sedation in gastrointestinal endoscopy: protocol for a systematic review and meta-analysis

作者：Qin, Xiaoyu[1];Lu, Xiaoting[2];Tang, Lu[2,3];Wang, Chunai[3];Xue, Jianjun[3]

第一作者：Qin, Xiaoyu

通信作者：Wang, CA[1]

机构：[1]Shanghai East Hosp, Dept Anesthesiol, Shanghai, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Anesthesia & Pain Med Ctr, Lanzhou, Peoples R China

第一机构：Shanghai East Hosp, Dept Anesthesiol, Shanghai, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Anesthesia & Pain Med Ctr, Lanzhou, Peoples R China.

年份：2023

卷号：13

期号：5

外文期刊名：BMJ OPEN

收录：;Scopus(收录号：2-s2.0-85160746452);WOS:【SCI-EXPANDED(收录号:WOS:001007725500004)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 81760892, 82260973) and Science and Technology Project of Gansu Province (No. 20JR10RA435, 20YF3FA020).

语种：英文

外文关键词：endoscopy; anaesthetics; clinical pharmacology; protocols & guidelines

摘要：IntroductionPainless gastrointestinal endoscopy is being increasingly practised in the clinical field. The management and choice of sedation are important during the endoscopy procedure to reduce patient discomfort and facilitate high disease detection rates. Ciprofol is principally an agonist of the gamma-aminobutyric acid type A receptor; it comprises the active ingredient HSK3486, which is similar to the currently used intravenous anaesthetic propofol in clinical practice. A systematic review and meta-analysis comparing ciprofol and propofol will be conducted to assess their efficacy and safety during endoscopy. Before starting the study, we describe the specific protocol of this systematic review.Methods and analysisThis protocol was prepared in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015. The following databases will be searched: Embase, Cochrane Library, PubMed, Web of Science, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database and a clinical trial registry. The database search strategy will adopt a combination of subject words and free words. Randomised controlled trials related to ciprofol use for sedation during gastrointestinal endoscopy will also be included. Based on the inclusion and exclusion criteria, two researchers will independently screen the articles and extracted data. Following the qualitative evaluation of each study, analysis will be conducted using Review Manager software.Ethics and disseminationThe protocol for this systematic review and meta-analysis involves no individual patient data; thus, ethical approval is not required. This will be the first meta-analysis to assess the sedation efficacy of ciprofol and provide evidence to clinicians for decision-making. The results will be disseminated through conference presentations and publications in peer-review journals related to this field.PROSPERO registration numberCRD42022370047.