文献类型：期刊文献

英文题名：Olfactory Senses Modulate Food Consumption and Physiology in Drosophila melanogaster

作者：He, Jianzheng[1,2,3];Tuo, Wenjuan[1,2];Zhang, Xueyan[4];Dai, Yuting[4];Fang, Ming[1,2];Zhou, Ting[1];Xiu, Minghui[1,3,4];Liu, Yongqi[1,3]

第一作者：和建政;何建政

通信作者：Xiu, MH[1];Liu, YQ[1];Xiu, MH[2];Liu, YQ[2];Xiu, MH[3]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2022

卷号：16

外文期刊名：FRONTIERS IN BEHAVIORAL NEUROSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000787914300001)】；

语种：英文

外文关键词：olfaction; food consumption; physiology; stress resistance; Drosophila melanogaster

摘要：Both sensory and metabolic processes guide food intake. Olfactory inputs help coordinate food appreciation and selection, but their role in food consumption and post-feeding physiology remains poorly understood. In this study, using Drosophila melanogaster as a model system, we investigated the effects of olfactory sensory neurons (OSNs) on food consumption, metabolism, and stress responses. We found that dysfunction of OSNs affects diverse processes, including decreased food consumption, increased triacylglycerol level, enhanced stress resistance to starvation or desiccation, and decreased cold resistance. Decreased neuropeptide F receptor (NPFR) level or increased insulin activity in OSNs inhibited food consumption, while impaired NPF signaling or insulin signaling in OSNs increased resistance to starvation and desiccation. These studies provide insights into the function of the olfactory system in control of feeding behaviors and physiology.