文献类型：期刊文献

英文题名：Potential role of lncRNA LOXL1-AS1 in human cancer development: a narrative review

作者：Tang, Mingzheng[1,2,3,4];Rong, Yao[1,2,3,4];Liu, Songhua[1,2];Wu, Zhihang[1];Ma, Guorong[1];Li, Xiaofeng[1];Cai, Hui[2,3,4,5]

第一作者：Tang, Mingzheng

通信作者：Cai, H[1];Cai, H[2];Cai, H[3];Cai, H[4]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Gen Surg Clin Med Ctr, 160 Donggang West Rd, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China;[4]Gansu Prov Hosp, Natl Hlth Council Key Lab Diag & Therapy Gastroint, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Gen Surg Clin Med Ctr, 160 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Prov Hosp, Natl Hlth Council Key Lab Diag & Therapy Gastroint, Lanzhou 730000, Peoples R China;[4]corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China.

年份：2024

卷号：13

期号：4

起止页码：1997

外文期刊名：TRANSLATIONAL CANCER RESEARCH

收录：;Scopus(收录号：2-s2.0-85193011976);WOS:【SCI-EXPANDED(收录号:WOS:001229464400010)】；

基金： This work was supported by grants from National Natural Science Foundation of China (No. 82360498) , Gansu Joint Scientific Research Fund Major Project (No. 23JRRA1537) , Key Talent Project of Gansu Province of the Organization Department of Gansu Provincial Party Committee (No. 2020RCXM076) , Gansu Provincial Youth Science and Technology Fund Program (No. 21JR7RA642) , and Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 21GSSYC-2) .

语种：英文

外文关键词：Lysyl oxidase-like protein 1-antisense RNA1 (LOXL1-AS1); long non-coding RNA (lncRNA); cancer; biomarker; therapeutic target

摘要：Background and Objective: Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs consisting of more than 200 nucleotides that are widely involved in various physiological and pathobiological processes in the body. LncRNA plays a crucial role in tumorigenesis and development with its unique functions, such as playing a role in a variety of biological processes of malignant tumors as a cancerpromoting factor or a cancer-suppressor factor. Lysyl oxidase-like protein 1-antisense RNA1 (LOXL1AS1) is a novel functional lncRNA recently reported. This article reviews the current findings on the role of LOXL1-AS1 in cancer, and discusses the potential clinical significance and application prospects, in order to provide a theoretical basis and reference for the clinical diagnosis, treatment and screening of prognostic markers for malignant tumors. Methods: The PubMed and Embase databases were searched using the keywords "cancer" or "tumor" or "neoplasm" and "LOXL1-AS1" for publications from 2018 to the present. The English literature was searched, with a focus on relevant articles. These articles validated the role and mechanism of LOXL1-AS1 in different cancers. Key Content and Findings: LOXL1-AS1 is a recently reported novel lncRNA, which is abnormally expressed and upregulated in more than ten cancers, and is positively correlated with adverse clinical features and poor prognosis in cancer patients. LOXL1-AS1 competently binds to a variety of microRNAs to regulate the expression of downstream target genes and regulate related signaling pathways, including proliferation, migration, invasion and inhibition of malignant biological behaviors such as apoptosis. Conclusions: LOXL1-AS1 is expected to become a novel biomarker for cancer diagnosis and treatment, with great potential as an independent prognostic indicator.