文献类型：期刊文献

英文题名：Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila

作者：Han, Shuzhen[1,2,3];Xiu, Minghui[1,2,4,5];Li, Shuang[3,5];Shi, Yan[1,2,3];Wang, Xiaoqian[1,2,3];Lin, Xingyao[5];Cai, Hui[6,7];Liu, Yongqi[1,2,5];He, Jianzheng[1,2,3,6,7]

第一作者：Han, Shuzhen

通信作者：Liu, YQ[1];He, JZ[1];Liu, YQ[2];He, JZ[2];Cai, H[3];He, JZ[3]

机构：[1]Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis & Prevent, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial L, Lanzhou 730000, Peoples R China;[6]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China;[7]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis & Prevent, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：159

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85146477520);WOS:【SCI-EXPANDED(收录号:WOS:000922677500001)】；

基金：The authors appreciated the financial support received from the National Natural Science Foundation of China (No. 82104562) , The 2021 Central-Guided Local Science and Technology Development Fund (No. ZYYDDFFZZJ-1) , "Double First Class" Scientific Research Key Project in Gansu (No. GSSYLXM-05) , Pharmaceutical Research project of Gansu Provincial Drug Administration (No. 2022GSMPA004) , Graduate Innovation and Entrepreneurship Fundation of Gansu University of Chinese Medicine (Nos. 2022CX33) .

语种：英文

外文关键词：Cytarabine; Side effects; Drosophila melanogaster; Intestine; Apoptosis

摘要：Cytarabine (Ara-C) is a widely used drug in acute myeloid leukemia (AML). However, it faces serious challenges in clinical application due to serious side effects such as gastrointestinal disorders and neurologic toxicities. Until now, the mechanism of Ara-C-induced damage is not clear. Here, we used Drosophila melanogaster (fruit fly) as the in vivo model to explore the side effects and mechanism of Ara-C. Our results showed that Ara-C supple-mentation delayed larval development, reduced lifespan, impaired locomotor capacity, and increased suscepti-bility to stress response in adult flies. In addition, Ara-C led to the intestinal morphological damage and ROS accumulation in the guts. Moreover, administration of Ara-C promoted gene expressions of Toll pathway, IMD pathway, and apoptotic pathway in the guts. These findings raise the prospects of using Drosophila as in vivo model to rapidly assess chemotherapy-mediated toxicity and efficiently screen the protective drugs.