文献类型：期刊文献

中文题名：强直性脊柱炎成骨相关通路及中医药干预的研究进展

英文题名：Research Progress on Osteogenic Pathways Associated with Ankylosing Spondylitis and Traditional Chinese Medicine Interventions

作者：苏瑾[1];杨娟娟[1];李浩林[1];王振东[1];芦栋生[1];陈平[2];王海东[2]

第一作者：苏瑾

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医院,甘肃兰州730050

第一机构：甘肃中医药大学

年份：2025

卷号：36

期号：10

起止页码：1808

中文期刊名：中药新药与临床药理

外文期刊名：Traditional Chinese Drug Research and Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：甘肃省科技计划项目(23JRRA1535)。

语种：中文

中文关键词：强直性脊柱炎;病理性新骨形成;成骨通路;Wnt/β-catenin信号通路;BMP/Smad信号通路;中医药;研究进展

外文关键词：ankylosing spondylitis;pathological new bone formation;osteogenic pathways;Wnt/β-catenin signaling pathway;BMP/Smad signaling pathway;traditional Chinese medicine;research progress

摘要：强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎症性疾病,主要累及中轴关节,严重者可发生脊柱畸形和关节强直,导致残疾。病理性新骨形成是导致AS患者关节强直、脊柱畸形的病理基础。成骨通路与AS病理性新骨形成密切相关。中药具有多成分、多靶点、多通路的作用特点,临床治疗AS疗效确切。该文通过分析、归纳与AS病理性新骨形成相关的成骨通路(Wnt/β-catenin、BMP/Smad信号通路)及中医药抑制成骨通路治疗AS病理性新骨形成的研究进展,可为中医药治疗AS提供科学依据。
Ankylosing spondylitis(AS)is a chronic inflammatory disease primarily affecting the axial joints,with severe cases leading to spinal deformities and joint ankylosis,resulting in disability.Pathological new bone formation is the pathological basis for joint ankylosis and spinal deformities in AS patients.Osteogenic pathways are closely associated with pathological new bone formation in AS.Traditional Chinese medicine(TCM)exhibits multi-component,multi-target,and multi-pathway therapeutic characteristics,demonstrating clinically validated efficacy in AS treatment.This review analyzes and summarizes the osteogenic pathways(Wnt/β-catenin and BMP/Smad signaling pathways)involved in pathological new bone formation in AS,as well as the research progress on TCM interventions targeting these pathways to inhibit pathological new bone formation.The aim is to provide scientific evidence for TCMbased treatment of AS.