文献类型：期刊文献

英文题名：Research progress on the effects of discoidin domain receptor 1 (DDR1) on the colorectal cancer tumor microenvironment

作者：Zhang, Jiali[1];Liu, Huixiu[1];Zhang, Chiyu[1];Bin, Xiong[2]

第一作者：张家莉;张佳丽

通信作者：Bin, X[1]

机构：[1]Gansu Univ Chinese Med, Coll Clin Med 1, Lanzhou, Peoples R China;[2]Gansu Prov Cent Hosp, Gansu Prov Matern & Child Healthcare Hosp, Med Oncol Dept, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Cent Hosp, Gansu Prov Matern & Child Healthcare Hosp, Med Oncol Dept, Lanzhou 730000, Gansu, Peoples R China.

年份：2026

外文期刊名：ONCOLOGY IN CLINICAL PRACTICE

收录：WOS:【ESCI(收录号:WOS:001754406600001)】；

基金：Funding This research was sponsored by Science and Tech-nology Department of Gansu Province (Grant number: 24JRRA615) , and the Excellent Talents Introduction and Doctoral Startup Fund Project (Grant number: GMCCH2024-2-6) .

语种：英文

外文关键词：discoidin domain receptor 1; tumor microenvironment; colorectal cancer; DDR1 antibody

摘要：Colorectal cancer (CRC) ranks among the most common malignant tumors worldwide, and epidemiological data show that its incidence is increasing year by year. In recent years, immune checkpoint inhibitors (ICIs) have demonstrated promising clinical efficacy across multiple solid tumors, including their use as third-line therapy for advanced CRC. However, a subset of patients exhibits poor treatment response due to primary or secondary resistance, particularly among those with mismatch repair proficient (pMMR) and/or microsatellite stable (MSS) CRC patients. Discoidin domain receptor 1 (DDR1), as a novel receptor tyrosine protein kinase, plays a pivotal role in tumor cell proliferation, differentiation, migration, and invasion, and it is even closely associated with the tumor microenvironment (TME). This review will elucidate the role of DDR1 in the TME and the progress of DDR1 antibodies in CRC research. It will also explore whether DDR1 can enhance CRC treatment efficacy when combined with other therapeutic approaches by modulating the TME.