文献类型：期刊文献

中文题名：中药注射液治疗高血压病脑出血的网状Meta分析

英文题名：Network Meta-analysis of Chinese medicine injections in treatment of hypertensive intracerebral hemorrhage

作者：任鹏[1,2];曹璐[1,2];赵信科[1,2];朱贝贝[1,2];刘凯[1,2]

第一作者：任鹏

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学循证医学中心,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：47

期号：13

起止页码：3637

中文期刊名：中国中药杂志

外文期刊名：China Journal of Chinese Materia Medica

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；PubMed;

基金：国家中医药循证能力建设项目(2019XZZX-XXG002);甘肃中医药大学2019级研究生创新基金项目(2021CX31);甘肃省高等学校创新基金项目(2021B-172)。

语种：中文

中文关键词：中药注射液;高血压病脑出血;网状Meta分析

外文关键词：Chinese medicine injection;hypertensive intracerebral hemorrhage;network Meta-analysis

摘要：为系统评价中药注射液治疗高血压病脑出血的疗效和安全性,计算机检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、维普(VIP)和中国生物医学文献服务系统(SinoMed),收集建库至2021年12月30日所发表的中药注射液治疗高血压病脑出血的随机对照试验(RCTs),采用RevMan 5.3、Stata 15.0软件进行数据分析。最终纳入63项RCTs,包括5953例患者。试验组共涉及9种中药注射液,分别为丹参注射液、丹红注射液、七叶皂苷钠注射液、清开灵注射液、复方麝香注射、舒血宁注射液、银杏达莫注射液、银杏内酯注射液、醒脑静注射液。网状Meta分析疗效排序结果显示:(1)神经功能改善有效率方面,累计概率排名曲线下面积(SUCRA)排序为外科手术+西医常规联合丹红注射液>联合醒脑静注射液>联合银杏内酯注射液>联合复方麝香注射>联合丹参注射液>联合七叶皂苷钠注射液>联合清开灵注射液>联合舒血宁注射液>联合银杏达莫注射液;(2)美国国立卫生研究院卒中量表(NIHSS)评分方面,SUCRA排序为外科手术+西医常规联合醒脑静注射液>联合复方麝香注射液>联合银杏达莫注射液>联合银杏内酯注射液>联合丹红注射液>联合七叶皂苷钠注射液;(3)格拉斯哥昏迷量表(GCS)评分方面,SUCRA排序为外科手术+西医常规联合银杏达莫注射液>联合清开灵注射液>联合七叶皂苷钠注射液>联合丹红注射液>联合银杏内酯注射液>联合醒脑静注射液;(4)残余脑血肿量方面,SUCRA排序为外科手术+西医常规联合七叶皂苷钠注射液>联合醒脑静注射液>联合丹红注射液>联合银杏内酯注射液>联合舒血宁注射液>联合复方麝香注射液。安全性方面,试验组不良反应/事件少于对照组。结果表明,在外科手术+西医常规治疗的基础上,联合中药注射液可提高高血压病脑出血的临床效果,但鉴于不同治疗措施间纳入的质量、研究数量存在较大差异,中药注射液的SUCRA排序结果还有待今后开展更多高质量的多中心、大样本、随机双盲试验加以佐证。
To systematically evaluate the efficacy and safety of Chinese medicine injections in the treatment of hypertensive intracerebral hemorrhage,we collected the relevant randomized controlled trials(RCTs)by computer retrieval from PubMed,EMbase,Cochrane Library,Web of Science,Wanfang,CNKI,VIP,and CBM within the timespan from inception to December 30,2021.The obtained index data were analyzed by RevMan 5.3 and Stata 15.0.Finally,63 RCTs were selected for analysis,involving 5953 patients.The experimental groups involved 9 Chinese medicine injections,including Danshen Injection,Danhong Injection,Sodium Aescinate Injection,Qingkailing Injection,Compound Shexiang Injection,Shuxuening Injection,Yinxing Damo Injection,Ginkgolide Injection,and Xingnaojing Injection.The network Meta-analysis showcased the following trends.(1)The surface under the cumulative ranking curve(SUCRA)in improving neurological function ranked in the order of surgical operation+conventional treatment of western medicine combined with Danhong Injection>combined with Xingnaojing Injection>combined with Ginkgolide Injection>combined with Compound Shexiang Injection>combined with Danshen Injection>combined with Sodium Aescinate Injection>combined with Qingkailing Injection>combined with Shuxuening Injection>combined with Yinxing Damo Injection.(2)In terms of National Institutes of Health stroke scale(NIHSS)score,the SUCRA ranked in the order of surgical operation+conventional treatment of western medicine combined with Xingnaojing Injection>combined with Compound Shexiang Injection>combined with Yinxing Damo Injection>combined with Ginkgolide Injection>combined with Danhong Injection>combined with Sodium Aescinate Injection.(3)In terms of Glasgow coma scale(GCS)score,the ranking of SUCRA was surgical operation+conventional treatment of western medicine combined with Yinxing Damo Injection>combined with Qingkailing Injection>combined with Sodium Aescinate Injection>combined with Danhong Injection>combined with Ginkgolide Injection>combined with Xingnaojing Injection.(4)The SUCRA in volume of residual cerebral hematoma ranked in the order of surgical operation+conventional treatment of western medicine combined with Sodium Aescinate Injection>combined with Xingnaojing Injection>combined with Danhong Injection>combined with Ginkgolide Injection>combined with Shuxuening Injection>combined with Compound Shexiang Injection.The experimental group had lower incidence of adverse reactions than the control group.The results of network Meta-analysis suggest that on the basis of surgical operation+conventional treatment of western medicine,the application of Chinese medicine injections can improve the efficacy of treating hypertensive intracerebral hemorrhage.However,in view of the great differences in the quality and number of studies included for different therapies,the SUCRA of Chinese medicine injections need to be further verified with high-quality multi-center,large-sample,randomized double-blind trials.