文献类型：期刊文献

英文题名：Research progress on T-cell responses in Staphylococcus aureus infections

作者：Li, Xupeng[1];Wang, Ruidan[2];Yan, Wentong[1];Guan, Jiarui[1];Pan, Haibang[1,3];Wang, Bo[2]

第一作者：李旭萍;李兴平

通信作者：Pan, HB[1];Wang, B[2];Pan, HB[3]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med Lanzhou, Sch Nursing, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med Lanzhou, Sch Nursing, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-105044397988);WOS:【SCI-EXPANDED(收录号:WOS:001809651300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Natural Science Foundation of China (No. 82560941), Gansu Provincial Key Talent Program (2025RCXM032), Open Fund Project of Gansu Provincial Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine (ZDSYS-KJ-2024-008), Gansu Provincial Higher Education Institution Faculty Innovation Fund Project (2025A-119), Gansu Provincial Department of Science and Technology Natural Science Fund (24JRRA1024), Gansu Provincial Department of Education Graduate Student "Innovation Star" Project (2026CXZX-926), Gansu Provincial Department of Science and Technology Project (2023KCZD-13), the 2019-2020 Open Project of Gansu Research Center of Traditional Chinese Medicine (zyzx-2020-13), and the General Project of Gansu Provincial Administration of Traditional Chinese Medicine (GZKP-2020-37).

语种：英文

外文关键词：immune evasion; immunoregulatory strategies; T-cell dysregulation; T-cell response; Staphylococcus aureus

摘要：Introduction: Staphylococcus aureus is a common Gram-positive pathogen capable of causing a wide range of severe infections. T cells are key adaptive immune effectors in S. aureus infection, and their response patterns and functional states strongly influence bacterial clearance, inflammatory regulation, and clinical outcomes. Methods: This narrative review summarizes recent evidence on T-cell responses in S. aureus infection, with emphasis on major T-cell subsets, context-dependent immune dysregulation, immune evasion, immunopathology, and potential immunoregulatory strategies. Results: Current evidence indicates that Th1/Th17 responses contribute to antimicrobial defense, whereas regulatory T cells may limit inflammatory damage but may also favor chronic colonization. Across different infection sites and disease stages, CD8+ T cells and innate-like T-cell populations, including gamma delta T cells, MAIT cells, and NKT cells, display marked functional heterogeneity. Recent advances in single-cell omics, immunometabolism, and immune checkpoint research have further clarified the dynamic changes in T-cell responses during S. aureus infection. Discussion: T-cell responses in S. aureus infection are highly context-dependent. A better understanding of these immune programs may inform future prevention and treatment strategies, including vaccines and targeted immunomodulatory interventions.