文献类型：期刊文献

中文题名：水蛭地龙有效组分及其配伍防治肾纤维化的研究进展

英文题名：Research Progress on the Effective Components of Leech and Earthworm and Their Compatibility in Preventing and Treating Renal Fibrosis

作者：马海兰[1];马鸿斌[2];李旭萍[2];魏锦慧[2];何彩苹[1];李根生[1];翟书玲[1]

第一作者：马海兰

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：37

期号：1

起止页码：187

中文期刊名：中医药临床杂志

外文期刊名：Clinical Journal of Traditional Chinese Medicine

基金：甘肃省名中医传承工作室建设项目(马鸿斌)(编号:甘财社〔2022〕105号);甘肃省中医药管理局科技科研课题(编号GZK-2019-30);2023年甘肃省教育科技创新项目(甘肃省教育厅:高校教师创新基金项目编号:2023B-106);兰州市科技计划项目资助(2022年兰州市科技发展指导性计划项目编号:2022-5-111)。

语种：中文

中文关键词：水蛭;地龙;有效组分;肾纤维化

外文关键词：Leech;Earthworm;Effective components;Renal fibrosis

摘要：肾纤维化(renal fibrosis,RF)是各种慢性肾脏病(chronic kidney disease,CKD)的主要病理基础,以细胞外基质(extracellular matrix,ECM)的异常沉积为特征。因此,CKD的治疗以抗肾脏纤维化为关键。西医以对症治疗及替代治疗为主,但其疗效及患者接受度有限。中医药在治疗CKD中优势独特,具有不良反应小及患者接受度高等特点。目前,中药单味药物、其有效组分及其配伍在防治RF中的应用广泛。水蛭地龙作为血肉有情之品,临床常相须为用。作者就近年水蛭、地龙有效组分及其配伍防治RF的临床及实验研究进行综述,为中医药治疗CKD提供理论依据。
Renal fibrosis(RF)is the main pathological basis of various chronic kidney diseases(CKD),characterized by abnormal deposition of extracellular matrix(ECM).Therefore,the key to the treatment of CKD is to fight against renal fibrosis.Western medicine mainly focuses on symptomatic treatment and replacement therapy,but its efficacy and patient acceptance are limited.Traditional Chinese medicine has unique advantages in the treatment of CKD,with few adverse reactions and high patient acceptance.At present,single Chinese medicine,its effective components and their compatibility are widely used in the prevention and treatment of RF.Leech and earthworm are both flesh and blood products,and are often used together in clinical practice.This article reviews the clinical and experimental studies on the effective components of leeches and earthworms and their compatibility in the prevention and treatment of RF in recent years,providing a theoretical basis for the treatment of CKD with traditional Chinese medicine.