文献类型：期刊文献

中文题名：基于数据挖掘技术研究中医药治疗绒毛膜下血肿的组方配伍规律

英文题名：The Compatibility Law of Prescription in the Treatment of Subchorionic Hematoma in Modern Chinese Medicine Based on Data Mining Technology

作者：窦艳猛[1];武权生[1];岳斌[1];李曼[1];李新月[1];王悦[1];殷甜甜[1]

第一作者：窦艳猛

机构：[1]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：32

期号：8

起止页码：114

中文期刊名：中国民族民间医药

外文期刊名：Chinese Journal of Ethnomedicine and Ethnopharmacy

基金：甘肃省高等学校创新基金项目(2021B-171);甘肃省优秀研究生“创新之星”项目(2021CXZX-763)。

语种：中文

中文关键词：绒毛膜下血肿;组方规律;数据挖掘;关联规则;聚类分析

外文关键词：Subchorionic Hematoma;Formation Law;Data Mining;Association Rules;Clustering Analysis

摘要：目的:将整理好的中医药治疗绒毛膜下血肿的文献,采用数据挖掘分析并总结该病的用药规律和组方特点。方法:从中国知网数据库(CNKI)、万方数据(WANFANG DATA)、中文科技期刊全文数据库(VIP)和中国生物医学文献数据库(CBM)检索建库至2021年12月30日发表的运用中医药治疗绒毛膜下血肿的文献,将符合要求的文献进行筛选和数据提取,采用IBM SPSS Statistics 22、IBM SPSS Modeler 18统计临床用药频数频率、常用药对及药物组合,采用关联规则、聚类分析对药物关联规则及核心药物组合进行分析。结果:共筛选出符合条件的中药处方76首,涉及中药117味,药性以平、微温为主,药味以甘居多,归经以肝、脾、肾经最多,功效分类以补虚药、止血药为主;其中使用频次≥20的中药有15味,其中菟丝子的使用频次最高;菟丝子20g的剂量使用频次最高;通过关联规则分析,获关联度较高的药物组合23对;聚类分析获药物分类6种。结论:研究发现中医药治疗绒毛膜下血肿以补虚药、止血药为主,常与药性平、微温,药味苦、甘,归脾、肝、肾经的药物配伍使用,对中医临床治疗绒毛膜下血肿具有一定的借鉴意义。
Objective The sorted literature of TCM treatment of subchorionic hematoma was analyzed and summarized by using data mining.Methods Literatures on the application of traditional Chinese medicine in the treatment of subchorionic hematoma published between the establishment of the database and December 30,2021 were retrieved from From China National Knowledge Infrastructure(CNKI),Wanfang Data(WANFANG DATA),Chinese Science and Technology Periodicals Full-text Database(VIP)and China Biomedical Literature Database(CBM),and the literatures that met the requirements were screened and data extracted.IBM SPSS Statistics 22 and IBM SPSS Modeler 18 were used to calculate clinical medication frequency,common drug pairs and drug combinations,and association rules and cluster analysis were used to analyze drug association rules and core drug combinations.Results A total of 76 TCM prescriptions were screened,involving 117 TCM ingredients.The drug properties were mainly flat and mild,the drug flavor was mostly ganzhu,the meridian of return was mostly liver,spleen and kidney,and the efficacy classification was mainly deficiency tonic and hemostatic drugs.Among them,15 Chinese herbs were used with frequency≥20,among which dodder was the most frequently used.Cuscuta 20g was the most frequently used.By association rule analysis,23 pairs of drug combinations with high correlation degree were obtained.Six drug categories were obtained by cluster analysis.Conclusion It is found that TCM treatment of subchorionic hematoma is mainly composed of tonifying drugs and hemostatic drugs,which are often used in combination with drugs of flat,lukewarm,bitter and sweet taste,and belong to the spleen,liver and kidney meridian.It has certain reference significance for TCM clinical treatment of subchorionic hematoma.