文献类型：期刊文献

中文题名：传统“热补针法”治疗类风湿关节炎的中枢及外周镇痛机理研究

英文题名：Study on the central and peripheral mechanism of analgesia in treatment of rheumatoid arthritis by traditional "heat-enforcing acupuncture"

作者：刘世琼[1];杜小正[1];秦晓光[1];骆文郁[1];赵彬元[1]

第一作者：刘世琼

机构：[1]甘肃中医学院

第一机构：甘肃中医药大学

年份：2006

卷号：25

期号：11

起止页码：36

中文期刊名：上海针灸杂志

外文期刊名：Shanghai Journal of Acupuncture and Moxibustion

收录：CSTPCD

基金：江苏省教育厅2002年度高校省级重点实验室开放课题(KJS02045)

语种：中文

中文关键词：热补针法;类风湿关节炎;痛阈;镇痛

外文关键词：Heat-enforcing acupuncture ;Rheumatoid arthritis; Pain threshold; Analgesia

摘要：目的 观察传统“热补针法”对类风湿关节炎的镇痛效应和探索其中枢、外周镇痛机理。方法 将健康2—3月龄青紫蓝家兔50只在测定痛阈后，按随机表分组法随机分为空白组、模型组、内服“虺痹冲剂组（药物组）、捻转针法组（捻转组）和热补针法组（热补组）5组。后4组以卵蛋白诱导关节炎疼痛模型。分别对各组进行处理后，比较各组家兔痛阈和中枢、外周镇痛物质的改变。结果 各治疗组在痛阈升高的同时，脑脊液和外周组织中的镇痛物质也有不同程度的改变。其中，热补组脑脊液中的内啡肽（β-EP）、八肽胆囊收缩素（CCK8）、腰髓P物质（SP）和外周局部组织中的B-内啡肽（β-EP）、亮啡肽（LEK）含量明显升高（P〈0．01），外周局部组织中的前列腺素E2（PGE2）含量明显降低（P〈0．01）。具有较好的中枢和外周镇痛效应。其作用优于药物组和捻转组（P〈0．01或P〈0．05）。结论 传统“热补针法”对类风湿关节炎具有显著的中枢、外周镇痛效应。
Projective To investigate the curative effect of traditional ＂teat-enforcing acupuncture＂ on rheumatoid arthritis and its central and peripheral mechanism of analgesia. Methods Fifty healthy rabbits aged 2-3 months were randomly allocated, according to a random number table, to blank, model, oral Bi powder （medication）, needle-twirling acupuncture （needle-twirling） and heat-enforcing acupuncture （heat-enforcing） groups after determination of pain threshold. A model of arthritis pain was made by induction with egg albumin in the latter 4 groups. After individual treatment, pain threshold, and central and peripheral analgesic substances were compared between different groups of rabbits. Results Analgesic substances in cerebrespinal fluid and peripheral tissues changed in varying degrees with a rise in pain threshold in the different treatment groups. In the heat-enforcing group, β-endorphin and 8-peptide cholecystokinin contents of cerebrospinal fluid, substance P content of the lumbar spinal cord, and β-endorphin and leuenkephalin contents of peripheral local tissues significantly increased （ P 〈0.01 ） and prostaglandin E2 content of peripheral local tissues significantly decreased （P 〈0.01 ）. There were good central and peripheral analgesic effects. The effect was better in the heat-enforcing group than in the medication group and in the needle-twirhng group. Conclusion Traditional ＂ heat-enforcing acupuncture＂ has marked central and peripheral analgesic effects in treating rheumatoid arthritis.