文献类型：期刊文献

英文题名：Expression of miR-146a-5p in patients with intracranial aneurysms and its association with prognosis

作者：Zhang, H. -L.[1];Li, L.[2];Cheng, C. -J.[1];Sun, X. -C.[1]

第一作者：Zhang, H. -L.

通信作者：Sun, XC[1]

机构：[1]Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med, Lanzhou, Gansu, Peoples R China

第一机构：Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China

通信机构：[1]corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China.

年份：2018

卷号：22

期号：3

起止页码：726

外文期刊名：EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

收录：;Scopus(收录号：2-s2.0-85042882164);WOS:【SCI-EXPANDED(收录号:WOS:000425735100022)】；

语种：英文

外文关键词：Intracranial aneurysms; microRNAs; miR-146a-5p; Prognosis

摘要：OBJECTIVE: The study aims to detect the association of miR-146a-5p with intracranial aneurysms (IAs). PATIENTS AND METHODS: The expression of miR-146a-5p was compared from plasma samples between 72 patients with intracranial aneurysms (lAs) and 40 healthy volunteers by quantitative Real-time polymerase chain reaction (qRT-PCR). Statistical analysis was performed to analyze the relationship between miR-146a-5p expression and clinical data and overall survival (OS) time of lAs patients. Univariate and multivariate Cox proportional hazards have also been performed. RESULTS: Notably, higher miR-146a-5p expression was found in plasma samples from 72 patients with intracranial aneurysms (lAs) compared with 40 healthy controls. Higher miR-146a-5p expression was significantly associated with rupture and Hunt-Hess level in lAs patients. Kaplan-Meier survival analysis verified that higher miR-146a-5p expression predicted a shorter overall survival (OS) compared with lower miR-146a-5p expression in lAs patients. Univariate and multivariate Cox proportional hazards demonstrated that higher miR-146a-5p expression, rupture, and Hunt-Hess were independent risk factors of OS in patients with intracranial aneurysms (lAs). CONCLUSIONS: MiR-146a-5p expression may serve as a biomarker for predicting prognosis in patients with lAs.