文献类型：期刊文献

英文题名：Ferroptosis: Regulatory mechanisms and potential targets for bone metabolism: A review

作者：Zhang, Yongjie[1];Hu, Kangyi[1];Shang, Zhengya[1];Yang, Xiaorui[1];Cao, Linzhong[1,2]

第一作者：张玉洁;张亚娟;张亚菊

通信作者：Cao, LZ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：103

期号：39

起止页码：e39158

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85205275699);WOS:【SCI-EXPANDED(收录号:WOS:001322380900048)】；

基金：This work was supported by the National Natural Science Foundation of China [grant numbers 82160915] and the Gansu University of Chinese Medicine Graduate Innovation Fund [grant numbers 2023CX14].

语种：英文

外文关键词：bone homeostasis; ferroptosis; iron; organelles; signal pathway

摘要：Bone homeostasis is a homeostasis process constructed by osteoblast bone formation and osteoclast bone resorption. Bone homeostasis imbalance and dysfunction are the basis for the development of various orthopedic diseases such as osteoporosis, osteoarthritis, and steroid-induced avascular necrosis of femoral head. Previous studies have demonstrated that ferroptosis can induce lipid peroxidation through the generation of reactive oxygen species, activate a number of signaling pathways, and participate in the regulation of osteoblast bone formation and osteoclast bone resorption, resulting in bone homeostasis imbalance, which is an important factor in the pathogenesis of many orthopedic diseases, but the mechanism of ferroptosis is still unknown. In recent years, it has been found that, in addition to iron metabolism and intracellular antioxidant system imbalance, organelle dysfunction is also a key factor affecting ferroptosis. This paper takes this as the starting point, reviews the latest literature reports at home and abroad, elaborates the pathogenesis and regulatory pathways of ferroptosis and the relationship between ferroptosis and various organelles, and summarizes the mechanism by which ferroptosis mediates bone homeostasis imbalance, with the aim of providing new directions for the research related to ferroptosis and new ideas for the prevention and treatment of bone and joint diseases.