文献类型：期刊文献

中文题名：细胞程序性死亡在骨质疏松症中的研究进展

英文题名：Research progress of programmed cell death in osteoporosis

作者：海云翔[1];巩彦龙[2];宋敏[1];董万涛[2];蒋宜伟[1];王凯[1]

第一作者：海云翔

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：29

期号：1

起止页码：89

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金(82160916,81960878);甘肃省教育厅产业支撑计划项目(2022CYZC-52);甘肃省优秀研究生“创新之星”项目(2022CXZX-731);甘肃中医药大学“岐黄英才”博导基金项目(2022-01);甘肃省优秀博士生项目(zzJR5RA574)。

语种：中文

中文关键词：骨质疏松;细胞凋亡;坏死性凋亡;铁死亡;细胞焦亡

外文关键词：osteoporosis;apoptosis;necroptosis;ferroptosis;pyroptosis

摘要：骨质疏松症(osteoporosis,OP)是多种病理因素导致的全身性骨代谢疾病。近来年,因高发病率、致残率及尚未明确的发病机制使其成为全球关注的公共健康问题。过去普遍认为细胞凋亡是唯一受调控的细胞死亡方式,细胞坏死不受调控。随着现代分子生物学技术的不断发展,发现细胞坏死亦可被某些基因和蛋白通路调控。凋亡、坏死性凋亡、铁死亡和焦亡等均属于细胞程序性死亡(programmedcelldeath,PCD),其是生物发育和病理特征的重要组成部分。PCD可影响骨代谢微环境及骨代谢平衡,在OP的发生发展中具有重要作用,笔者就上述细胞程序性死亡方式与OP的相关研究进行综述,以期为OP的防治提供新策略。
Osteoporosis(OP)is a systemic bone metabolic disease caused by a variety of pathological factors.In recent years,it has become a public health problem of global concern because of its high incidence and disability rate and unknown pathogenesis.In the past,it was generally believed that the only regulated mode of cell death was apoptosis,and cell necrosis was not regulated.With the continuous development of modern molecular biology technology,it is found that cell necrosis is also regulated by some genes and protein pathways.Therefore,apoptosis,necroptosis,ferroptosis,and pyroptosis all belong to programmed cell death(programmed cell death,PCD),which is an important part of biological development and pathological characteristics.PCD may affect bone metabolic microenvironment and bone metabolic balance,and play an important role in the occurrence and development of OP.This paper reviews the research in the relationship between PCD and OP,in order to provide a new strategy for the prevention and treatment of OP.