文献类型：期刊文献

中文题名：知柏地黄丸对肾上腺皮质激素型肾阴虚幼龄大鼠血浆CORT、ACTH、CRH及肾上腺指数和组织学结构的影响

英文题名：Effects of ZhiBaiDiHuang Pill on Levels of CORT,ACTH,CRH in Blood and Index of Adrenal and Tissue Structure of Adrenal in Young Rats Model of Kidney-Yin Defiency of Adrenal Cortex Hormone

作者：史正刚[1];潘曌曌[1];张士卿[1]

第一作者：史正刚

机构：[1]甘肃中医学院儿科教研室,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2006

卷号：12

期号：3

起止页码：167

中文期刊名：中国中医基础医学杂志

外文期刊名：JOURNAL OF BASIC CHINESE MEDICINE

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：知柏地黄丸;CORT;ACTH;CRH;肾上腺指数;组织学结构

外文关键词：ZhiBaiDiHuangWan ; CORT; ACTH ; CRH ; Weight-index; Tissue structure of Adrenal

摘要：目的:探讨知柏地黄丸对肾阴虚幼龄大鼠血CORT、ACTH、CRH及肾上腺指数和肾上腺组织学结构的影响。方法:用氢化可的松每日腹腔注射法造成肾阴虚模型。结果:与空白组比较,模型组cAMP含量无变化,cGMP含量明显降低,cAMP/cGMP含量明显升高,说明造模成功。与模型组比较,知柏地黄丸高剂量组可明显提高血浆CORT、ACTH、CRH及肾上腺指数。其疗效明显优于六味地黄丸组。知柏地黄丸低剂量组与六味地黄丸组比较,治疗效果无显著差异。镜下观察可见,模型组肾上腺各层明显变薄,皮质层萎缩尤为明显,部分细胞退行性变,类脂质空泡减少。知柏地黄丸治疗后,肾上腺各层增厚,退行性变细胞明显减少,类脂质空泡较多。结论:知柏地黄丸能显著提高激素性肾阴虚幼龄大鼠血浆CORT、ACTH、CRH及肾上腺指数,故证实该药可有效拮抗外源性糖皮质激素对HPA轴的抑制作用。
Objective： To study the effects of ZhiBaiDiHuangWan on levels of CORT,ACTH,CRH in blood and weight-index,tissue structure of adrenal in young rats model of Yin defiency. Methods：A deficiency of Yin young rat model was established using high dose hydrocortisone. 75 young rats wee divided into 5 groups randomly： normal group, model group, high, low dose of ZhiBaiDiHuangWan group and LiuWeiDiHuangWan group,the effect of high,low dose of ZhiBaiDiHuangWan and LiuWeiDiHuangWan were studied. Results： in model group,the contents of cGMP in blood was much lower,the ratio of cAMP/cGMP was much higher than normal group. ZhiBaiDiHuagWan and LiuWeiDiHuangWan could significantly increase CORT ,ACTH and CRH in blood, also increase weight-index of adrenal, while the increasnlent of high dose of ZhiBaiDiHuangWan was higher than LiuWeiDiHuangWan. Conclusion： ZhiBaiDiHuangWan can obviously improve CORT, ACTH,CRH in blood and weight-index of adrenal, so it was suggested that ZhiBaiDiHuangWan can significantly oppose the retraint from Gc to HPA.