文献类型：期刊文献

英文题名：Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection

作者：Yin, Rong[1,2];Yang, Linpeng[3,4];Hao, Ying[5];Yang, Zhiqi[1,6];Lu, Tao[7];Jin, Wanjun[3];Dan, Meiling[1,8];Peng, Liang[9];Zhang, Yingjie[1,10];Wei, Yaxuan[2];Li, Rong[1,6];Ma, Huiping[3];Shi, Yuanyuan[11];Fan, Pengcheng[3,12]

第一作者：Yin, Rong

通信作者：Fan, PC[1];Shi, YY[2];Fan, PC[3]

机构：[1]Lanzhou Gen Hosp, Dept Neurol, Lanzhou 730050, Peoples R China;[2]Gansu Prov Cent Hosp, Dept Neurol, Lanzhou 730070, Peoples R China;[3]Lanzhou Gen Hosp, Dept Pharm, Lanzhou 730050, Peoples R China;[4]Ctr Gansu Prov Vaccine Engn Res, Dept Res 4, Lanzhou 730046, Peoples R China;[5]Weill Cornell Med Coll, Pathol & Lab Med, New York, NY 10065 USA;[6]Lanzhou Univ Second Hosp, Dept Neurol, Lanzhou 730030, Peoples R China;[7]Beijing Univ Chinese Med, Sch Life Sci, Beijing 102488, Peoples R China;[8]Chongqing Univ, Dept Neurol, Fuling Hosp, Chongqing 408000, Peoples R China;[9]Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China;[10]Gansu Univ Chinese Med, Clin Med Sch 1, Lanzhou 730030, Peoples R China;[11]Beijing Univ Chinese Med, Shenzhen Res Inst, Shenzhen 518118, Peoples R China;[12]Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China

第一机构：Lanzhou Gen Hosp, Dept Neurol, Lanzhou 730050, Peoples R China

通信机构：[1]corresponding author), Lanzhou Gen Hosp, Dept Pharm, Lanzhou 730050, Peoples R China;[2]corresponding author), Beijing Univ Chinese Med, Shenzhen Res Inst, Shenzhen 518118, Peoples R China;[3]corresponding author), Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China.

年份：2022

卷号：19

期号：1

外文期刊名：JOURNAL OF NEUROINFLAMMATION

收录：;Scopus(收录号：2-s2.0-85127693446);WOS:【SCI-EXPANDED(收录号:WOS:000778015400005)】；

基金：This work was supported by National Natural Science Foundation of China (No. 81402848) and Biosafety Project Foundation (No.19SWAQ13).

语种：英文

外文关键词：Japanese encephalitis; Cerebrospinal fluid; Proteomics; Dementia; Cognitive impairment

摘要：Background: Cognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted treatment strategy. Methods: A cerebrospinal fluid (CSF) proteomic profiling study was performed including 26 patients with JE in Gansu province of China from June 2017 to October 2018 and 33 other concurrent hospitalized patients who were excluded central nervous system (CNS) organic or CNS infection diseases. The clinical and proteomics data of patients with JE were undergoing combined analysis for the first time. Results: Two subtypes of JE associated with significantly different prognoses were identified. Compared to JE1, the JE2 subtype is associated with lower overall survival rate and a higher risk of cognitive impairment. The percentages of neutrophils (N%), lymphocyte (L%), and monocytes (M%) decreased in JE2 significantly. Conclusions: The differences in proteomic landscape between JE subgroups have specificity for the prognosis of cognitive impairment. The data also provided some potential target proteins for treatment of cognitive impairments caused by JE.