文献类型：期刊文献

英文题名：Research progress on the role of lncRNA, circular RNA, and microRNA networks in regulating ferroptosis in osteosarcoma

作者：Yan, Chunlu[1];Dou, Yinnan[2];Xia, Ruoliu[2];Liu, Shiqing[2];Fu, Jianchao[2];Li, Duo[2];Wang, Rong[1];Tie, Feng[1];Li, Linxin[1];Jin, Hua[3];An, Fangyu[4]

第一作者：颜春鲁

通信作者：Jin, H[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：176

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85195643813);WOS:【SCI-EXPANDED(收录号:WOS:001255184700001)】；

基金：This study was supported by the Gansu Province Higher Education Innovation Fund Project (2022A-072) ; the Young Doctor Fund Program of Colleges and Universities, Gansu Province (2022QB-091) ; the Key Scientific Research Program of "Double first-class", Gansu Province (GSSYLXM-05) and Talent Training Platform Construction of Employment and Entrepreneurship for College Students majoring in Traditional Chinese Medicine based on Comprehensive Skills and Innovative Abilities (202402) .

语种：英文

外文关键词：Osteosarcoma; Ferroptosis; NcRNAs; Molecular mechanism

摘要：Noncoding RNAs (ncRNAs) do not participate in protein-coding. Ferroptosis is a newly discovered form of cell death mediated by reactive oxygen species and lipid peroxidation. Recent studies have shown that ncRNAs such as microRNAs, long noncoding RNAs, circular RNAs, and ferroptosis are involved in the occurrence and development of osteosarcoma (OS). Studies have confirmed that ncRNAs participate in the development of OS by regulating the ferroptosis. However, systematic summary on this topic are still lacking. This review summarises the potential role of ncRNAs in the diagnosis, treatment, drug resistance, and prognosis of OS and the basis for diagnosing, preventing, and treating clinical OS and developing effective drugs. This review summarises the latest research progress on ncRNAs that regulate ferroptosis in OS, attempts to clarify the molecular mechanisms by which ncRNAs regulate ferroptosis in the pathogenesis of OS, and elaborates on the involvement of ferroptosis in OS from the perspective of ncRNAs.