文献类型：期刊文献

中文题名：大黄素防治慢性肝病作用机制的研究现状

英文题名：Current status of research on the mechanism of action of emodin in the prevention and treatment of chronic liver diseases

作者：陈雅洁[1];王昕[1];武云娟[1];苏莹[1];王钰涵[2];张金雪[1];姚凝[3];秦英[1];左小宁[1]

第一作者：陈雅洁

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]苏州大学苏州医学院,江苏苏州215123;[3]甘肃中医药大学第一临床医学院,兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2026

卷号：42

期号：1

起止页码：228

中文期刊名：临床肝胆病杂志

外文期刊名：Journal of Clinical Hepatology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(82160845);甘肃省自然科学基金(25JRRA254,20JR5RA181);甘肃省中医药高水平重点科研项目(GZKZ2024-36);甘肃中医药大学引进人才科研启动基金(2024-YJRC-01);甘肃中医药大学中医药科学研究与创新基金资助项目(KCZD2018-1);甘肃中医药大学研究生创新创业基金项目(2025CXCY-008);甘肃省教育厅高等教育创新基金项目(2021B-173);甘肃省兰州市城关区科技计划项目(2021-2-5)。

语种：中文

中文关键词：大黄素;肝疾病;信号传导

外文关键词：Emodin;Liver Diseases;Signal Transduction

摘要：慢性肝病是指肝脏因长期受到各种损伤,出现持续时间超过6个月且不可逆性病理改变的疾病。大黄素(EMO)是一种来源于大黄的天然蒽醌衍生物,其药理作用已被广泛研究,表现出多种生物特性并涉及多个信号分子和途径。目前针对慢性肝病的治疗方案以西药或手术治疗为主,由于副作用、高成本等多种原因,治疗推进受限。EMO因其天然来源和疗效,在治疗慢性肝病方面具有独特的优势,现已成为研究热点。本文通过总结梳理EMO对慢性肝病的治疗作用并探讨其机制,以期为慢性肝病的中医药治疗与临床药物研发提供一定的科学依据。
Chronic liver diseases are a group of diseases in which the liver is subjected to a variety of injuries over a long period of time,resulting in irreversible pathological changes that last longer than 6 months.Emodin(EMO)is a natural anthraquinone derivative derived from Rheum officinale,and its pharmacological effect has been extensively studied,exhibiting a variety of biological properties and involving multiple signaling molecules and pathways.Western medicine or surgical treatment is currently the main treatment regimen for chronic liver diseases,and the advance in treatment is limited by various reasons such as side effects and high costs.Due to its natural origin and efficacy,EMO has unique advantages in the treatment of chronic liver diseases and has now become a research hotspot.This article summarizes the therapeutic effect of EMO on chronic liver diseases and its mechanism,in order to provide a certain scientific basis for the traditional Chinese medicine treatment of chronic liver diseases and the development of drugs in clinical practice.