文献类型：期刊文献

英文题名：Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease

作者：He, Jianzheng[1,2];Li, Xu[3];Yang, Shipei[1];Li, Yaling[1,2];Lin, Xingyao[4];Xiu, Minghui[3];Li, Xuexiang[5];Liu, Yongqi[1,4]

第一作者：和建政;何建政

通信作者：Liu, YQ[1];Xiu, MH[2];Liu, YQ[3];Li, XX[4]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[4]Gansu Univ Ttadit Chinese Med, Key Lab Transfer Dunhuang Med & Prov & Ministeria, Lanzhou 730000, Peoples R China;[5]Northwestern Polytech Univ, Coll Chem & Chem Engn, Xian 710072, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Ttadit Chinese Med, Key Lab Transfer Dunhuang Med & Prov & Ministeria, Lanzhou 730000, Peoples R China;[4]corresponding author), Northwestern Polytech Univ, Coll Chem & Chem Engn, Xian 710072, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2021

卷号：12

期号：17

起止页码：7816

外文期刊名：FOOD & FUNCTION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000670334000001)】；

基金：We thank the Bloomington Stock Center (BSC) for generously providing fly stocks. The authors appreciate the financial support received from the National Natural Science Foundation of China (81960793), Scientific Research and Innovation Fund Project (no. KCZD2018-2), Provincial Key Talent Project (no. GZT2020-9-1), Provincial University Industry Support Project in Gansu (no. 2020C-15), Gansu High Education Innovation Ability Improvement Project (no. 2019A-071) and Gansu Province Youth Talent Support Project (GXH2020626-20).

语种：英文

摘要：Gastrodin is the main bioactive ingredient of a famous Chinese herb Rhizoma Gastrodiae. Many studies have reported that gastrodin has antioxidative and neuroprotective effects, although its effect on longevity and the mechanism of neuroprotection have not been well studied. Here, we use Drosophila melanogaster as a model to investigate the longevity and neuroprotective effects of gastrodin. Gastrodin significantly extended the lifespan, increased the climbing ability, enhanced the resistance to oxidative stress, increased the enzyme activities of superoxide dismutase (SOD) and catalase (CAT), and promoted the expression of anti-oxidative genes in old flies. The food intake, reproduction and starvation resistance were not affected in flies treated with gastrodin. Moreover, gastrodin delayed the onset of Parkinson-like phenotypes in Pink1(B9) mutant flies, including the prolongation of the lifespan, rescue of the climbing ability, rescue of the progressive loss of a cluster of dopaminergic neurons in the protocerebral posterial lateral 1 region, and increase of the dopamine content in the brain. Gastrodin did not ameliorate the tau-induced neurobehavioral deficits in the fly AD model of taupathy. Together, these results indicate that gastrodin could prolong the lifespan by regulating the antioxidant ability, and protect against neurodegeneration in the Pink1(B9) model of PD. This suggests that gastrodin can be considered as an ideal therapeutic candidate for drug development towards anti-aging.