文献类型：期刊文献

英文题名：Remodeling and Regenerative Properties of Fully Absorbable Meshes for Abdominal Wall Defect Repair: A Systematic Review and Meta-Analysis of Animal Studies

作者：Wang, Zhe[1,3];Hu, Kaiyan[1,3];Jiang, Yanbiao[1];Zhang, Xu[2];Zhao, Peng[2];Li, Xingzhi[5];Ding, Fengxing[1];Liu, Chen[1];Yi, Shaowei[1];Ren, Ziyu[6];Liu, Wenbo[2];Ma, Bin[1,4]

第一作者：Wang, Zhe

通信作者：Ma, B[1];Liu, WB[2];Ma, B[3]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]Natl Med Prod Adm, Ctr Med Device Evaluat, Beijing 100081, Peoples R China;[3]Key Lab Evidence Based Med & Knowledge Translat Ga, Lanzhou 730000, Peoples R China;[4]Key Lab Evidence Based Med Gansu Prov, Lanzhou 730000, Peoples R China;[5]Xinxiang Med Univ, Sch Basic Med, Xinxiang 453000, Peoples R China;[6]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]corresponding author), Natl Med Prod Adm, Ctr Med Device Evaluat, Beijing 100081, Peoples R China;[3]corresponding author), Key Lab Evidence Based Med Gansu Prov, Lanzhou 730000, Peoples R China.

年份：2024

卷号：10

期号：6

起止页码：3968

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20242216175270);Scopus(收录号：2-s2.0-85194278961);WOS:【SCI-EXPANDED(收录号:WOS:001233768000001)】；

基金：This work was supported by the National Key Research & Development Program of China [grant numbers 2022YFC2409800, 2022YFC2409801] and Science & Technology Project of Lanzhou City [grant numbers 2022-3-8].

语种：英文

外文关键词：absorbable material; abdominal wall defect; remodeling and regeneration; animal experiment; systematic review

摘要：Fully absorbable meshes can repair abdominal wall defects and effectively reduce the incidence of complications, but different types of fully absorbable meshes have different remodeling and regeneration effects. In order to investigate and compare the effects of different fully absorbable meshes on remodeling and regeneration in animals and reduce the biological risk of clinical translation, SYRCLE was adopted to evaluate the methodological quality of the included studies, and GRADE and ConQual were used to evaluate the quality of evidence. According to the inclusion and exclusion criteria, a total of 22 studies related to fully absorbable meshes were included in this systematic review. These results showed that fiber-based synthetic materials and fiber-based natural materials exhibited better restorative and regenerative effects indicated by infiltration and neovascularization, when compared with a porcine acellular dermal matrix. In addition, the human acellular dermal matrix was found to have a similar regenerative effect on the host extracellular matrix and scaffold degradation compared to the porcine acellular dermal matrix, porcine intestinal submucosa, and fiber-based natural materials, but it offered higher tensile strength than the other three. The quality of the evidence in this field was found to be poor. The reasons for downgrading were analyzed, and recommendations for future research included more rigor in study design, more transparency in result reporting, more standardization of animal models and follow-up time for better evaluation of the remodeling and regenerative performance of abdominal wall hernia repair meshes, and less biological risk in clinical translation.