文献类型：期刊文献

英文题名：Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

作者：Zhang, Maofu[1];Zhong, Jialin[1];Shen, Yanyun[1];Song, Zhongyang[2]

第一作者：Zhang, Maofu

通信作者：Song, ZY[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Oncol, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Oncol, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105001733653);WOS:【SCI-EXPANDED(收录号:WOS:001457818600001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by Gansu Province Major Science and Technology Special Project - Science and Technology Leading Talents Project (21ZDKA0014); Zhang Zhiming Studio Construction Project of State Administration of Traditional Chinese Medicine (Letter No. [2022] 245 of the State Administration of Traditional Chinese Medicine); Key Laboratory of Diagnosis and Treatment of Gastrointestinal Tumours of the National Health and Wellness Commission (NLDTG2020014); 2024 Longyuan Young Innovative and Entrepreneurial Talents Project (002104002); 2024 Gansu Provincial Science and Technology Department Key Research and Development Programme Project (24YFFA067); 2023 Lanzhou Municipal Science and Technology Programme Project (2023-2-49); 2024 Gansu Provincial TCM Management Project (GZKG-2024-60); 2023 Hospital Youth Project (gzfy-2023-9).

语种：英文

外文关键词：precancerous lesions of gastric cancer (PLGC); bile acids (BAs); gut microbiota; crosstalk mechanism; traditional Chinese medicine

摘要：As a critical juncture in the pathological continuum from gastritis to gastric cancer, precancerous lesions of gastric cancer (PLGC) are increasingly prevalent, significantly undermining the health of the global population. The primary constituents of bile, specifically bile acids (BAs), disrupt the equilibrium of gastric hormone secretion and compromise the structural integrity of the gastric mucosa, thereby facilitating gastric oncogenesis. Moreover, gut microbiota modulate host physiological and pathological processes through immune response regulation, metabolic pathway interference, and direct interaction with gastric tumor cells. Extensive research has elucidated that the metabolic dysregulation of BAs and gut microbiota, in concert with the resultant impairment of the gastric mucosa, are central to the pathogenesis of PLGC. In anticipation of future clinical preventive and therapeutic strategies, this review collates recent insights into the roles of BAs and gut bacteria in PLGC, examining their interplay and significance in the pathogenic mechanism of PLGC.