文献类型：期刊文献

英文题名：The Therapeutic Potential of Human Umbilical Cord Mesenchymal Stem Cell-derived Exosomes in Acute Radiation Intestinal Injury

作者：Yang, Gaosheng[1,2];Yu, Jianping[3];Yang, Yanping[1];Han, Xiaopeng[3];Wang, Jinbao[3];Wang, Hongyu[3];Li, Yanjie[3];Chen, Weikai[3]

第一作者：Yang, Gaosheng

通信作者：Chen, WK[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou Petrochem Gen Hosp, Affiliated Hosp 4, Dept Anorectal Surg, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[3]Gansu Prov Cent Hosp, Dept Gen Surg 1, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Cent Hosp, Dept Gen Surg 1, Lanzhou 730000, Peoples R China.

年份：2026

卷号：206

期号：1

起止页码：69

外文期刊名：RADIATION RESEARCH

收录：;Scopus(收录号：2-s2.0-105044929722);WOS:【SCI-EXPANDED(收录号:WOS:001821564300006)】；

基金：This research was supported by the Gansu Natural Science Foundation (Grant No. 23JRRA1386) and the Lanzhou Science and Technology Plan Project (Grant No. 2023-4-65) Gansu Province Youth Science and Technology Fund (24JRRA1119) , Gansu Provincial Hospital Fund (24GSSYB-12) , and Gansu Provincial Major Special Science and Technology Program (23ZDFA012) .

语种：英文

摘要：Radiation-induced bowel injury is a common complication of radiation therapy for pelvic or abdominal cancers, with its occurrence increasing worldwide. Current treatments face significant challenges, and the limitations of conventional methods highlight the urgent need for new therapeutic strategies and drugs. Mesenchymal stem cell-derived exosomes show promising potential in treating inflammatory diseases. In this study, an acute radiation-induced intestinal injury model was created in rats after exposure to a 10 Gy X-ray dose, after administration of human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-exo) via tail vein injection. The results showed that these exosomes (exos) enhanced survival, aided in functional recovery, reduced inflammation, decreased enterocyte death, and helped regenerate the intestinal lining. Additionally, bioinformatic analyses of gene expression and gene ontology (GO) enrichment were performed. Molecular validation revealed a significant increase in pyroptosis-related factors in the intestinal tissues after irradiation, indicating that cellular pyroptosis is a key mechanism. In conclusion, HUC-MSC-exos help maintain intestinal integrity and promote cell growth, suggesting they could be an effective treatment for radiation-induced intestinal injury. (c) 2026 by Radiation Research Society