文献类型：期刊文献

英文题名：Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton

作者：Gong, Yanlong[1];Ma, Xin[2];Wang, Lele[3];Zhang, Pengwei[2];Liu, Tingting[2];Li, Yuanzhen[1];Dong, Wantao[4]

第一作者：Gong, Yanlong

通信作者：Wang, LL[1];Dong, WT[2]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Intervertebral Disc Ctr, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Chinese Med, Lanzhou, Peoples R China;[3]Henan Univ Chinese Med, Clin Med Coll 2, Zhengzhou, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Dept Sports Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Henan Univ Chinese Med, Clin Med Coll 2, Zhengzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Sports Med, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001763917100001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the Training Program for National Young Qihuang Scholars (No. 9 (2026), Official Letter of Personnel Education, National Administration of Traditional Chinese Medicine); the Lanzhou Science and Technology Development Plan Project (2023-ZD-205); the Talent Innovation and Entrepreneurship Project of Chengguan District, Lanzhou (2023-rc-7); the Industry Support Program for Colleges and Universities in Gansu Province (2025CYZC-051); the Scientific Research Project of Gansu Provincial Administration of Traditional Chinese Medicine (GZKC-2025-70); and the Longyuan Young Talents Program of Gansu Province (001174005). All funders provided financial support for the design of the study, collection, analysis and interpretation of data, and the writing of the manuscript. No funder had any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

语种：英文

外文关键词：bone metabolism; gut microbiota; gut-bone axis; immune regulation; osteoporosis; probiotics; SCFAs

摘要：Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the "gut-bone axis," and this review consolidates its diverse mechanisms. GM-derived metabolites directly/indirectly modulate osteoclast/osteoblast activity. GM also regulates systemic immunity to influence the RANKL/OPG pathway and mediates endocrine signals. Furthermore, it modulates intestinal barrier integrity to facilitate mineral/vitamin absorption and interacts with the nervous system to form the "microbiota-gut-brain-bone" axis. GM imbalance, resulting from factors such as aging, hormonal shifts, or dietary habits, promotes the progression of OP through the perturbation of these networks. This review evaluates the therapeutic potential of GM-targeted interventions, including probiotics, prebiotics, and fecal microbiota transplantation, and underscores the GM as a pivotal therapeutic target, emphasizing that future therapeutic strategies for OP must incorporate the interconnected GM-bone axis for efficacious prevention and treatment.