文献类型：期刊文献

中文题名：针刺对创伤后应激障碍模型大鼠海马CAI和CA3区神经电生理活动的影响

英文题名：Effects of acupuncture on neuro-electrophysiological activities in hippocampal CAI and CA3 areas of rats with post-traumatic stress disorder

作者：赵中亭[1,2];赵怡坤[1];朱田田[1];邢家铭[3];卜筱梅[1];张彦峰[1];严兴科[1,2]

第一作者：赵中亭

机构：[1]Gansu University of Chinese Medicine, Lanzhou 730000, China;[2]Postdoctoral Research Station of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;[3]Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

第一机构：甘肃中医药大学

年份：2019

卷号：17

期号：2

起止页码：67

中文期刊名：Journal of Acupuncture and Tuina Science

外文期刊名：针灸推拿医学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：中国博士启科学基金第62批面上项目(No.2017M623269);2014年度国家自然科学基金地区项目(No.81460744);2013年度甘肃省自然科学研究基金计划项目(No. 1308RJZA150)。

语种：中文

中文关键词：针刺疗法;穴,百会;穴,内关;穴,神门;穴,太冲;应激障碍,创伤后;电生理学;大鼠

外文关键词：Acupuncture Therapy;Point, Baihui (GV 20);Point, Neiguan (PC 6);Point, Shenmen (HT 7);Point, Taichong (LR 3);Stress Disorders, Post-traumatic;Electrophysiology;Rats

摘要：目的:观察毫针针刺对创伤后应激障碍(PTSD)模型大鼠海马CA1和CA3区神经电生理活动特征量的影响。方法:将50只Sprague-Dawley(SD)大鼠随机分为空白组、模型组、抓取组、西药组和针刺组,每组10只。除空白组外,其他4组大鼠以复合应激法造模。造模同时西药组予以盐酸帕罗西汀灌胃,针刺组接受针刺干预,抓取组接受抓取固定,模型组和空白组不接受任何干预。干预14d后,通过在体多通道记录海马CA1和CA3区神经元集群放电,分析峰-峰间期(ISI)和功率谱密度(PSD)并绘图。结果:与空白组比较,模型组和抓取组CA1和CA3区ISI延长,PSD集中分布区域下移(PV0.05或P<0.01);与抓取组比较,西药组和针刺组CA1和CA3区ISI缩短,PSD集中分布区域上移(PC0.05或PV0.01);针刺组CA1和CA3区的ISI和PSD集中分布区域与西药组无统计学差异(均P>0.05)。结论:毫针针刺与盐酸帕罗西汀干预均可显著调节PTSD模型大鼠海马CA1和CA3区神经电生理活动特征量发放模式,可能是针灸干预促进PTSD恢复的机制之一。
Objective: To observe the effects of acupuncture on the characteristics of neuro-electrophysiological activity in hippocampal CAI and CA3 areas of rats with post-traumatic stress disorder (PTSD). Methods: Fifty Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, a grasping group, a Western medicine group and an acupuncture group, with 10 rats in each group. Except for the blank group, rats in the other 4 groups all received the combined stress modeling method. Rats in the Western medicine group were intragastrically administrated with paroxetine hydrochloride, those in the acupuncture group received acupuncture intervention, those in the grasping group received grasping fixation, and those in the model group and the blank group did not receive any in terve ntions. After 14 d of in terve ntion, the interspike in terval (ISI) and power spectral den sities (PSD) were an a lyzed and mapped by in vivo multiple channels to record the neuron clusters discharge in the hippocampal CAI and CA3 areas. Results: Compared with the blank group, ISI was proIonged in the CAI and CA3 areas of the model group and the grasping group, and the concentrated PSD distribution area moved down (Pv0.05 or P<0.01). Compared with the grasping group, the ISI of the CAI and CA3 areas in the Western medicine group and the acupuncture group was shortened, and the concentrated PSD distribution area moved up (P<0.05 or P<0.01). The ISI and PSD distributions in the CAI and CA3 areas of the acupuncture group were not statistically different from those in the Western medicine group (both P>0.05). Conclusion: Both acupuncture and paroxetine hydrochloride can significantly regulate the neuro-electrophysiology activity of hippocampal CAI and CA3 areas in PTSD rats, which may be one of the mechanisms of acupuncture intervention to promote PTSD recovery.