文献类型：期刊文献

中文题名：双侧卵巢原发性子宫内膜间质肉瘤1例并文献复习

英文题名：Primary bilateral ovarian endometrial stromal sarcoma:A case report and literature review

作者：李进[1];曹石[2];赵静[1];单莹莹[1];舍雅莉[1]

第一作者：李进

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]兰州大学第一医院病理科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：45

期号：9

起止页码：1258

中文期刊名：临床与病理杂志

外文期刊名：Journal of Clinical and Pathological Research

语种：中文

中文关键词：子宫外;子宫内膜间质肉瘤;卵巢;病理特征;盆腔肿物

外文关键词：extrauterine;endometrial stromal sarcoma;ovary;pathological features;pelvic mass

摘要：子宫内膜间质肉瘤(endometrial stromal sarcoma,ESS)是来源于间叶组织的恶性肿瘤,通常发生于子宫内,发生于子宫外而不影响子宫的情况较为罕见。本研究报告1例61岁女性ESS患者,该患者因体检时发现盆腔肿物,于2024年11月11日至兰州大学第一医院就诊,最终被确诊为双侧卵巢原发性低级别ESS(low-grade endometrial stromal sarcoma,LG-ESS),并伴随盆腔转移。患者接受了子宫、双侧附件切除术,右侧盆腔肿物切除术,以及直肠表面结节切除术。病理学检查结果显示肿瘤细胞表现出低级别特征,免疫组织化学分析结果证实肿瘤来源于间叶。双侧卵巢均受累在临床上极为罕见,本研究通过对该病例的深入探讨,明确了该疾病的临床病理特征,并指出在盆腔肿物的诊断中应警惕子宫外发生ESS的可能性。复习以往文献发现子宫外ESS的发病位置多样,其中以卵巢最为常见。在治疗方面,目前子宫外ESS大多数情况下参考子宫内ESS的治疗方案,未来需进行更大规模和更深入的研究,以进一步探讨和明确其临床病理特性及最佳治疗策略。本研究为子宫外ESS的临床实践提供了重要参考,有助于加深临床医师对该罕见病的认识,从而提升临床诊断的准确性。
Endometrial stromal sarcoma(ESS)is a malignant tumor originating from mesenchymal tissue and typically arises within the uterus.Extrauterine ESS that does not involve the uterus is extremely rare.We report the case of a 61-year-old woman who was found to have a pelvic mass during a routine physical examination and presented to the First Hospital of Lanzhou University on November 11,2024.She was ultimately diagnosed with primary bilateral ovarian low-grade endometrial stromal sarcoma(LG-ESS)with pelvic metastasis.The patient underwent hysterectomy,bilateral salpingo-oophorectomy,excision of the right pelvic mass,and removal of nodules on the rectal surface.Pathological examination showed low-grade morphological features,and immunohistochemical analysis confirmed a mesenchymal origin of the tumor.Bilateral ovarian involvement is exceedingly rare.Through the detailed analysis of this case,we clarified the clinicopathological characteristics of this condition and emphasized that ESS should be considered in the differential diagnosis of pelvic masses arising outside the uterus.A review of the literature indicates that extrauterine ESS may occur in various anatomical sites,with the ovary being the most commonly affected location.Treatment of extrauterine ESS generally follows the therapeutic principles used for uterine ESS;however,larger-scale and more comprehensive studies are needed to elucidate its clinicopathological features and optimal management strategies.This case provides valuable reference for the clinical practice of extrauterine ESS and enhances clinicians’understanding and diagnostic accuracy of this rare disease.