文献类型：期刊文献

英文题名：From Traditional Efficacy to Drug Design: A Review of Astragali Radix

作者：Jin, Xiaojie[1,2,3];Zhang, Huijuan[1];Xie, Xiaorong[1];Zhang, Min[1];Wang, Ruifeng[2,3];Liu, Hao[1];Wang, Xinyu[1];Wang, Jiao[1];Li, Dangui[1];Li, Yaling[2,4];Xue, Weiwei[5];Li, Jintian[3];He, Jianxin[2,4];Liu, Yongqi[2,3];Yao, Juan[1,3]

第一作者：靳晓杰

通信作者：Yao, J[1];Liu, YQ[2];Liu, YQ[3];Yao, J[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Prov Key Lab Mol Med & Prevent Res Major Dis, Lanzhou 730000, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou 730000, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Sch Basic Med, Lanzhou 730000, Peoples R China;[5]Chongqing Univ, Innovat Drug Res Ctr, Sch Pharmaceut Sci, Chongqing, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov Key Lab Mol Med & Prevent Res Major Dis, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Tradit Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;

年份：2025

卷号：18

期号：3

外文期刊名：PHARMACEUTICALS

收录：;Scopus(收录号：2-s2.0-105001012308);WOS:【SCI-EXPANDED(收录号:WOS:001452237700001)】；

基金：This work was funded by Provincial University industry support project in Gansu (2022CYZC-54), National Natural Science Foundation of China (No. 82004202), National Natural Science Foundation of China (No. 82460862), 2021 Gansu Province Youth Science and Technology Talent Lift Project (GXH20210611-02).

语种：英文

外文关键词：Astragali Radix; review; botanical characteristics; phytochemistry; pharmacology; drug design

摘要：Astragali Radix (AR), a traditional Chinese herbal medicine, is derived from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (A. membranaceus var. mongholicus, AMM) or Astragalus membranaceus (Fisch.) Bge (A. membranaceus, AM). According to traditional Chinese medicine (TCM) theory, AR is believed to tonify qi, elevate yang, consolidate the body's surface to reduce sweating, promote diuresis and reduce swelling, generate body fluids, and nourish the blood. It has been widely used to treat general weakness and chronic illnesses and to improve overall vitality. Extensive research has identified various medicinal properties of AR, including anti-tumor, antioxidant, cardiovascular-protective, immunomodulatory, anti-inflammatory, anti-diabetic, and neuroprotective effects. With advancements in technology, methods such as computer-aided drug design (CADD) and artificial intelligence (AI) are increasingly being applied to the development of TCM. This review summarizes the progress of research on AR over the past decades, providing a comprehensive overview of its traditional efficacy, botanical characteristics, drug design and distribution, chemical constituents, and phytochemistry. This review aims to enhance researchers' understanding of AR and its pharmaceutical potential, thereby facilitating further development and utilization.