文献类型：期刊文献

英文题名：Syringin: a naturally occurring compound with medicinal properties

作者：Qian, Qingyuan[1,2];Pan, Jinchao[2,3];Yang, Jun[2,4];Wang, Renjie[2,4];Luo, Kai[2,4];Wu, Zhenhui[2];Ma, Shuhe[2,4];Wang, Yuguang[2];Li, Maoxing[1,2,4];Gao, Yue[2,3]

第一作者：Qian, Qingyuan

通信作者：Li, MX[1];Li, MX[2];Gao, Y[2];Gao, Y[3];Li, MX[4]

机构：[1]Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China;[2]Inst Radiat Med Sci, Beijing, Peoples R China;[3]Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China;[4]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China;[2]corresponding author), Inst Radiat Med Sci, Beijing, Peoples R China;[3]corresponding author), Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85200253858);WOS:【SCI-EXPANDED(收录号:WOS:001283175600001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by Traditional Chinese Medicine Innovation Team and Talent Support Program Project from National Administration of Traditional Chinese Medicine (ZYYCXTDD-202207).

语种：英文

外文关键词：syringin; extraction and separation; pharmacological activities; preparations and applications; pharmacokinetics

摘要：Syringin, a phenylpropanoid glycoside, is widely distributed in various plants, such as Acanthopanax senticosus (Rupr. et Maxim.) Harms, Syringa reticulata (BL) Hara var. mandshurica (Maxim.) Hara, and Ilex rotunda Thumb. It serves as the main ingredient in numerous listed medicines, health products, and foods with immunomodulatory, anti-tumor, antihyperglycemic, and antihyperlipidemic effects. This review aims to systematically summarize syringin, including its physicochemical properties, plant sources, extraction and separation methods, total synthesis approaches, pharmacological activities, drug safety profiles, and preparations and applications. It will also cover the pharmacokinetics of syringin, followed by suggestions for future application prospects. The information on syringin was obtained from internationally recognized scientific databases through the Internet (PubMed, CNKI, Google Scholar, Baidu Scholar, Web of Science, Medline Plus, ACS Elsevier, and Flora of China) and libraries. Syringin, extraction and separation, pharmacological activities, preparations and applications, and pharmacokinetics were chosen as the keywords. According to statistics, syringin can be found in 23 families more than 60 genera, and over 100 species of plants. As a key component in many Chinese herbal medicines, syringin holds significant research value due to its unique sinapyl alcohol structure. Its diverse pharmacological effects include immunomodulatory activity, tumor suppression, hypoglycemic action, and hypolipidemic effects. Additionally, it has been shown to provide neuroprotection, liver protection, radiation protection, cardioprotection, and bone protection. Related preparations such as Aidi injection, compound cantharidin capsule, and Tanreqing injection have been widely used in clinical settings. Other studies on syringin such as extraction and isolation, total synthesis, safety profile assessment, and pharmacokinetics have also made progress. It is crucial for medical research to deeply explore its mechanism of action, especially regarding immunity and tumor therapy. Meanwhile, more robust support is needed to improve the utilization of plant resources and to develop extraction means adapted to the needs of industrial biochemistry to further promote economic development while protecting people's health.