文献类型：期刊文献

中文题名：NLRP3炎症小体在白血病中的研究进展

英文题名：Research progress of NLRP3 inflammasome in the treatment of leukemia

作者：孙海燕[1,2];周士燕[1,3];张杉杉[2];张茜[1]

第一作者：孙海燕

机构：[1]中国人民解放军联勤保障部队第九四〇医院血液科,兰州730050;[2]甘肃中医药大学第一临床医学院,兰州730030;[3]西北民族大学医学院,兰州730030

第一机构：中国人民解放军联勤保障部队第九四〇医院血液科,兰州730050

年份：2025

卷号：54

期号：6

起止页码：1447

中文期刊名：重庆医学

外文期刊名：Chongqing Medical Journal

基金：甘肃省自然科学基金项目(21JRIRA183);甘肃省卫生健康行业科研计划项目(GSWSKY2021-044);西北民族大学中央高校重大需求培育项目(31920220110);联勤保障部队第九四〇医院基础和临床培育项目(2021yxky042)。

语种：中文

中文关键词：NLRP3炎症小体;激活通路;白血病;骨髓增生异常综合征;细胞焦亡

外文关键词：nucleotide binding oligomerization domain like receptor protein 3 inflammasome;activation pathway;leukemia;myelodysplastic syndrome;pyrodeath

摘要：核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体是一种细胞内多聚体蛋白复合物,它在炎症和免疫反应中发挥重要作用。近年来,关于NLRP3炎症小体在血液系统恶性肿瘤中的研究已成为热点话题。白血病是影响骨髓或淋巴细胞成熟和/或增殖的一大类克隆性血液恶性肿瘤,越来越多的研究显示,NLRP3炎症小体能参与白血病的发生发展,未来有望成为白血病重要的治疗靶点。该文综述了NLRP3炎症小体的结构、生物学功能、激活通路及其与不同类型的白血病关系的研究进展,并探讨了其在白血病治疗中的潜在应用前景。
The nucleotide binding oligomerization domain like receptor protein 3(NLRP3)inflammasome is an intracellular polymeric protein complex that plays an important role in inflammation and immune response.In recent years,the study of NLRP3 inflammasome in hematological malignancies has become a hot topic.Leukemia is a large group of clonal hematologic malignancies that affect the maturation and/or proliferation of bone marrow or lymphocytes.More and more studies have shown that NLRP3 inflammatory micromolecules are involved in the occurrence and development of leukemia,and it is expected to become an important therapeutic target for leukemia in the future.In this review,the structure,biological function,activation pathway of NLRP3 inflammasome and its relationship with different types of leukemia were reviewed,and its potential application in the treatment of leukemia was discussed.