文献类型：期刊文献

中文题名：清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期非小细胞肺癌临床研究

英文题名：Clinical Study on Qingfei Sanjie Pills Combined with Targeted Cryoablation Therapy for Treatment of Elderly Patients with Advanced Non-Small Cell Lung Cancer

作者：魏亚强[1];张晓飞[1];汪海燕[2]

第一作者：魏亚强

机构：[1]延安市人民医院;[2]甘肃中医药大学附属医院

第一机构：延安市人民医院

年份：2017

卷号：24

期号：11

起止页码：26

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

语种：中文

中文关键词：清肺散结丸;氩氦刀靶向冷冻治疗;老年;晚期;非小细胞肺癌

外文关键词：Qingfei Sanjie Pills; targeted cryoablation therapy; elderly; advanced; non small cell lung cancer

摘要：目的观察清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期非小细胞肺癌(NSCLC)的疗效及其对免疫功能的影响。方法采用抽签法将94例老年晚期NSCLC患者分为观察组与对照组各47例。2组均采用经皮穿刺氩氦刀靶向冷冻治疗,手术后复查CT,观察病灶情况。观察组并予清肺散结丸,每次1瓶,每日2次,口服,共治疗3个月。评价2组近期疗效,观察2组治疗前后Ig G、Ig A、CD3^+、CD4^+、CD8^+水平及术后并发症。观察2组1、2、3年生存率。结果观察组和对照组分别脱落2、3例。观察组总有效率为84.4%(38/45),对照组为65.9%(29/44),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后Ig G、Ig A、CD3^+、CD4^+、CD8^+水平明显升高(P<0.05),治疗组治疗后Ig G、Ig A、CD3^+、CD4^+、CD8^+水平高于对照组(P<0.05)。治疗后,观察组咳嗽加重、术后疼痛、痰中带血、发热及恶心呕吐的发生率均低于对照组(P<0.05)。观察组1、2、3年生存率分别为91.1%、75.6%、64.4%,对照组分别为79.5%、63.6%、52.3%,2组相同时点比较差异有统计学意义(P<0.05)。结论清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期NSCLC疗效较好,可改善患者免疫功能,提高生存率。
Objective To study the clinical efficacy of Qingfei Sanjie Pills combined with targeted cryoablation therapy on elderly patients with advanced non-small cell lung cancer（NSCLC） and its influence on the levels of immune function in patients. Methods Totally 94 elderly patients with NSCLC were divided into observation group and control group, with 47 cases in each group. Both groups were given targeted cryoablation therapy and under CT review after surgery to observe lesions condition. Observation group was given Qingfei Sanjie Pills, once a bottle, twice a day, orally, for three months. Recent efficacy of the two groups were evaluated. The levels of Ig G, Ig A, CD3＋, CD4＋, CD8＋, and complications in the two groups were detected. The survival rate of 1 year, 2 years and 3 years in the two groups were observed. Results Two cases in the observation group and three cases in the control group were invalid. The total effective rate was 84.4%（38/45） in observation group and 65.9%（29/44） in the control group, with statistical significance（P0.05）. After the treatment, the levels of Ig G, Ig A, CD3＋, CD4＋ and CD8＋ in the observation group were significantly higher than the control group（P0.05）. After treatment, the incidence rates of increased cough, postoperative pain, bloody sputum, fever and nausea and vomiting in the observation group were lower than the control group. The 1 year, 2 years and 3 years survival rates were 91.1%, 75.6% and 64.4% in observation group, and 79.5%, 63.6% and 52.3% in the control group, with statistical significance（P0.05）. Conclusion Qingfei Sanjie Pills combined with targeted cryoablation therapy on elderly patients with advanced NSCLC has good clinical efficacy, which can improve immune system of patients and increase survival rate.