文献类型：期刊文献

英文题名：Discussion on the treatment of diabetic kidney disease based on the "gut-fat-kidney" axis

作者：He, Yaping[1];Jia, Dengke[2];Chen, Wenying[1];Liu, Juan[1];Liu, Congrong[1];Shi, Xiaowei[3]

第一作者：He, Yaping

通信作者：Shi, XW[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Endocrinol, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Endocrinol, Lanzhou 730000, Peoples R China.

年份：2024

外文期刊名：INTERNATIONAL UROLOGY AND NEPHROLOGY

收录：;Scopus(收录号：2-s2.0-85209189270);WOS:【SCI-EXPANDED(收录号:WOS:001355689900001)】；

基金：National Natural Science Foundation of China, (No.81960888, No.82360884, No.82360955), (No.81960888, No.82360884, No.82360955), Gansu Association for Science and Technology Youth Science and Technology Talent Promotion Project, GXH202026-11, GXH202026-11, Lanzhou City Talent Innovation and Entrepreneurship Project, (2019-RC-62), (2019-RC-62)

语种：英文

外文关键词：Diabetic kidney disease; Intestinal flora; Brown adipose tissue; Gut-fat-kidney axis; Mechanism; Review

摘要：Diabetic kidney disease is the main cause of end-stage renal disease, and its prevention and treatment are still a major clinical problem. The human intestine has a complex flora of hundreds of millions of microorganisms, and intestinal microorganisms, and their derivatives are closely related to renal inflammatory response, immune response, and material metabolism. Brown adipose tissue is the main part of adaptive thermogenesis. Recent studies have shown that activating brown fat by regulating intestinal flora has good curative effects in diabetic kidney disease-related diseases. As an emerging medical concept, the "gut-fat-kidney" axis has received increasing attention in diabetic kidney disease and related diseases. However, the specific mechanism involved needs further study. A new theoretical basis for the prevention and treatment of diabetic kidney disease is presented in this article, based on the "gut-fat-kidney" axis.