文献类型：期刊文献

中文题名：复方苦参注射液联合西医治疗乳腺癌的应用与研究进展

英文题名：Application and Research Progress of Compound Kushen Injection Combined With WesternMedicine In The Treatment of Breast Cancer

作者：王丽[1,2];崔旭鑫[1,2];卫浩亮[1,2];张景惠[1,2];李京凯[1,2];杨孝来[1,2]

第一作者：王丽

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃省人民医院药剂科,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：33

期号：13

起止页码：54

中文期刊名：中国民族民间医药

外文期刊名：Chinese Journal of Ethnomedicine and Ethnopharmacy

基金：国家自然科学基金地区项目(No.81560595);甘肃省人民医院院内优秀硕/博士培育计划科研基金项目(22GSSYD-63)。

语种：中文

中文关键词：乳腺癌;联合治疗;苦参注射液;研究进展

外文关键词：Breast Cancer;Combination Therapy;Compound Kushen Injection;Research Progress

摘要：乳腺癌常用的治疗方式有放疗、化疗、分子靶向治疗、内分泌治疗和免疫治疗,这些治疗方式产生的不良反应较多,严重影响患者的生活质量。复方苦参注射液(compound kushen injection,CKI)是一种具有抗肿瘤作用的临床中医药制剂,与其他方式联用治疗乳腺癌时,具有增效减毒的作用。文章回顾了近十年CKI联合西医治疗乳腺癌的相关文献,得出CKI可通过PI3K-AKT和p53信号通路以及能量代谢等多种作用途径来治疗乳腺癌;在临床上与放疗和化疗联用情况较多,与内分泌治疗联用较少,暂无与免疫治疗联用情况。建议系统研究CKI中各组成药材中活性成分的相容性并与CKI进行比较,深入研究CKI联合西医抗癌药物的协同作用机制,充分发挥CKI的临床应用价值。
Breast cancer is the commonly used treatment methods include radiotherapy,chemotherapy,molecular targeted drugs therapy,endocrine therapy and immunotherapy,which have many adverse reactions and severe affect the patient s quality of life.Compound Kushen Injection(CKI)is a kind of clinical preparation of traditional Chinese medicine with anti-tumor effects,which can enhance the efficacy and reduce the toxicity when combined with other methods to treat breast cancer.This paper reviewed the literature on the treatment of breast cancer by CKI combined with western medicine in recent ten years,and concluded that CKI can treat breast cancer through various action pathways such as PI3K-AKT and p53 signaling pathways and energy metabolism,etc.In clinical practice,it is often used in combination with radiotherapy and chemotherapy,and rarely used in combination with endocrine therapy,and no combination with immunotherapy.It is suggested to systematically study the compatibility of active ingredients in each component of CKI and compare it with CKI,further study the synergistic mechanism of CKI and western anticancer drugs,and give full play to the clinical application value of CKI.