文献类型：期刊文献

英文题名：Balanced crystalloids for intravenous fluid therapy in critically ill and non-critically ill patients A protocol for systematic review and network meta-analyses

作者：Ma, Peifen[1,2];Wang, Bo[3];Zhang, Jun[4];Shen, Xiping[5];Yu, Liping[3];Dou, Xinman[1]

第一作者：Ma, Peifen

通信作者：Dou, XM[1]

机构：[1]Lanzhou Univ, Hosp 2, Dept Nursing, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Nursing, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Rehabil Ctr Hosp Gansu Prov, Dept Nursing, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Gansu, Peoples R China;[5]Lanzhou Univ, Sch Publ Hlth, Inst Epidemiol & Hlth Stat, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Dept Nursing, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Dept Nursing, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.

年份：2018

卷号：97

期号：51

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85058907638);WOS:【SCI-EXPANDED(收录号:WOS:000456334600070)】；

基金：This work is supported by the Longyuan Youth Innovation and Entrepreneurship Team Project (2018).

语种：英文

外文关键词：balanced crystalloids; critically ill patients; intravenous fluid therapy; network meta-analysis; non-critically ill patients

摘要：Background: The balanced crystalloids have become a substitute for saline for fluid resuscitation. Some studies have investigated the clinical effect and adverse event of differently balanced crystalloids, but they have no consistent conclusions. This study aims to assess and compare the effect of differently balanced crystalloids for intravenous fluid therapy in critically ill and non-critically ill patients using network meta-analysis (NMA). Methods: Electronic databases including PubMed, EMBASE, Cochrane Library, Web of Science, Clinical Trials.gov, and the International Clinical Trials Registry Platform (ICTRP) will be searched from inception to April 2018. We will include randomized controlled trials (ROTS) that reported the effect and adverse event of balanced crystalloids. Risk of bias assessment of the included RCTs will be conducted according to the Cochrane Handbook 5.1.0. A Bayesian NMA will be performed using R software. GRADE will be used to explore the quality of evidence. Results: The results of this NMA will be published in a peer-reviewed journal. Conclusion: This NMA will summarize the direct and indirect evidence to assess the effect of differently balanced crystalloids. Ethics and dissemination: Ethics approval and patient consent are not required as this study is an NMA based on published studies.