文献类型：期刊文献

英文题名：Effects of zoledronic acid and ibandronate in the treatment of cancer pain in rats with lung cancer combined with bone metastases

作者：Wang, Gengshen[1];Chen, Jiuyi[2];Ma, Ruofei[3];Xu, Weiyuan[4];Yan, Chunlu[5];Niu, Cunliang[1]

第一作者：Wang, Gengshen

通信作者：Chen, JY[1]

机构：[1]Wuwei Peoples Hosp, Dept Orthopaed, Wuwei 733000, Gansu, Peoples R China;[2]Wuwei Peoples Hosp, Dept Resp Med, 1 Xuanwu St, Wuwei 733000, Gansu, Peoples R China;[3]Gansu Prov Canc Hosp, Dept Oncol Surg, Wuwei 730050, Gansu, Peoples R China;[4]Lanzhou Univ, Dept Orthopaed, Hosp 2, Lanzhou 730030, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Anim Expt Ctr, Lanzhou 730020, Gansu, Peoples R China

第一机构：Wuwei Peoples Hosp, Dept Orthopaed, Wuwei 733000, Gansu, Peoples R China

通信机构：[1]corresponding author), Wuwei Peoples Hosp, Dept Resp Med, 1 Xuanwu St, Wuwei 733000, Gansu, Peoples R China.

年份：2018

卷号：16

期号：2

起止页码：1696

外文期刊名：ONCOLOGY LETTERS

收录：;Scopus(收录号：2-s2.0-85049443900);WOS:【SCI-EXPANDED(收录号:WOS:000444763100043)】；

语种：英文

外文关键词：ibandronate; zoledronic acid; lung cancer bone metastasis; rat model; efficacy

摘要：The aim of the study was to investigate the efficiency and safety of zoledronic acid and ibandronate in the treatment of rats with lung cancer combined with bone metastases. A total of 124 rats with lung cancer bone metastasis were established. Rats were randomly divided into A, B and C groups (n=30). Rats in group A were treated with ibandronate combined with zoledronic acid, rats in group B were treated with zoledronic acid monotherapy, and rats in group C were treated with ibandronate monotherapy. Rats in group A were injected subcutaneously with zoledronic acid 0.1 mg/kg and ibandronate 10 mu g/kg, once per week for 12 weeks; rats in group B were injected subcutaneously with zoledronic acid, and rats in group C were injected subcutaneously with ibandronate, the same method as the treatment group. The remaining 34 SD rats were not treated to serve as the control group. Treatment efficacy and physical improvement in 8 weeks were observed, and improvement of pain behavior in rats was evaluated to reflect the effect of drug treatment. Of the 30 rats in group A, 25 showed different degrees of remission, 5 rats showed no improvement and the effective rate was 83.3%. Of the 30 rats in group B, 21 showed different degrees of remission, 9 rats showed no improvement and the effective rate was 70%. Of the 30 rats in group C, 20 showed different degrees of remission, 10 rats showed no improvement and the effective rate was 66.7%. Statistically significant differences in total effective rate were found among three groups, and the combined method showed the highest effective rate (P<0.05). Ibandronate combined with zoledronic acid has a good therapeutic effect on cancer pain caused by bone metastases from lung cancer.