文献类型：期刊文献

中文题名：肿瘤细胞与肿瘤相关巨噬细胞之间的代谢串扰

英文题名：Metabolic Crosstalk between Tumor Cells and Tumor-Associated Macrophages

作者：王焕焕[1];董文浩[1];刘芳[1];陈彻[1]

第一作者：王焕焕

机构：[1]甘肃中医药大学公共卫生学院,兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2025

卷号：47

期号：11

起止页码：2959

中文期刊名：中国细胞生物学学报

外文期刊名：Chinese Journal of Cell Biology

基金：青年科技基金(批准号:22JR11RA124);甘肃省自然科学基金(批准号:20JR10RA311);甘肃省中医药科研项目(批准号:GZKZ-2024-37);甘肃中医药大学科学研究与创新基金(批准号:2022KCYB-2);兰州市科技计划(批准号:2023-2-12)资助的课题。

语种：中文

中文关键词：肿瘤细胞;肿瘤相关巨噬细胞;代谢;串扰;靶向治疗

外文关键词：tumor cells;tumor-associated macrophages;metabolism;crosstalk;targeted therapy

摘要：在肿瘤微环境(tumor microenvironment,TME)中,肿瘤相关巨噬细胞(tumor associatedmacrophages,TAMs)是最丰富的细胞群之一,在肿瘤发生、化疗耐药、免疫逃避和转移中起着关键作用。TAMs与肿瘤细胞之间存在重要的相互作用:代谢重编程可以赋予肿瘤细胞在TME中的生存优势,相应的代谢副产物可以影响TAMs的功能。此外,TAMs响应TME中存在的信号进行代谢重编程,这会影响其功能和癌症进展。确定影响肿瘤细胞与TAMs之间复杂相互作用的代谢变化是探索新的治疗方法的重要一步,从而增强其抗肿瘤活性。该文综述了肿瘤细胞与TAMs相互作用过程中的代谢变化,为抗肿瘤治疗提供新的靶点。
TAMs(tumor-associated macrophages)are one of the most abundant cell populations in the TME(tumor microenvironment)and play a key role in tumorigenesis,chemoresistance,immune evasion,and metastasis.There is an important interaction between TAMs and tumor cells:metabolic reprogramming can confer a survival advantage on tumor cells in TME,and corresponding metabolic by-products can affect the function of TAMs.In addition,TAMs undergo metabolic reprogramming in response to signals present in the TME,which can affect their function and cancer progression.Identifying metabolic changes that affect the complex interactions between tumor cells and TAMs is an important step in the exploration of new treatments that enhance their tumoricidal potential.This article summarizes the metabolic alterations during tumor cell-TAM interactions,highlighting potential targets for cancer treatment.