文献类型：期刊文献

英文题名：Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

作者：Zhang, Wangzheqi[1];Mu, Chenyang[2];Zhao, Rui[3];Ma, Runwei[4,5,6];Liu, Xuehai[7];Zhang, Haoling[8];Wang, Zengwu[9,10];Zhang, Jing-jing[4,5,6]

第一作者：Zhang, Wangzheqi

通信作者：Zhang, JJ[1];Zhang, JJ[2];Zhang, JJ[3];Zhang, HL[4];Wang, ZW[5];Wang, ZW[6]

机构：[1]Naval Med Univ, Sch Anesthesiol, Shanghai, Peoples R China;[2]Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Nursing, Shanghai, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[4]Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming, Peoples R China;[5]Yunnan Prov Cardiovasc Clin Med Ctr, Kunming, Peoples R China;[6]Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming, Peoples R China;[7]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[8]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town, Malaysia;[9]Peking Union Med Coll, Natl Clin Res Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Fuwai Hosp,Natl Ctr Cardiovasc Dis,Div Prevent & C, Beijing, Peoples R China;[10]Chinese Acad Med Sci, Beijing, Peoples R China

第一机构：Naval Med Univ, Sch Anesthesiol, Shanghai, Peoples R China

通信机构：[1]corresponding author), Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming, Peoples R China;[2]corresponding author), Yunnan Prov Cardiovasc Clin Med Ctr, Kunming, Peoples R China;[3]corresponding author), Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming, Peoples R China;[4]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town, Malaysia;[5]corresponding author), Peking Union Med Coll, Natl Clin Res Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Fuwai Hosp,Natl Ctr Cardiovasc Dis,Div Prevent & C, Beijing, Peoples R China;[6]corresponding author), Chinese Acad Med Sci, Beijing, Peoples R China.

年份：2026

卷号：7

期号：6

外文期刊名：MEDCOMM

收录：Scopus(收录号：2-s2.0-105040399563);WOS:【ESCI(收录号:WOS:001777687700001)】；

基金：This research was supported by grants from Science and Technology Department of Yunnan Province-Kunming Medical University, Kunming Medical Joint Special Project-Surface Project, China, No. 202401AY070001-164; and Yunnan Provincial Department of Science and Technology Science and Technology Plan Project-Major Science and Technology Special Projects, China, No. 202405AJ310003; and the Yunnan Pan Xiangbin Expert Workstation under the Yunnan Provincial Project for Scientific and Technological Talents and Platforms Project, No. 202305AF150069.

语种：英文

外文关键词：cardiovascular diseases; chromatin remodeling; enhancer rewiring; epigenetic regulation; noncoding RNAs; precision epigenetic therapy

摘要：Cardiovascular diseases (CVDs) arise as the product of multiple factors, including genetic predisposition and environmental exposure, but the molecular and cellular interplays underlying such a pathogenetic process leading to sustained pathological conditions remain largely unknown. A growing body of evidence indicates that epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, noncoding RNAs, and RNA modifications, are important for cardiovascular development, adaptation, and disease. However, findings from these studies are fragmented across different genomic contexts or disease-focused scenarios, lacking systematic integration for a global view connecting epigenetic dynamics to cardiovascular phenotypes and their clinical implications. An overall picture of epigenetic modulation in CVDs is therefore provided. Common epigenetic mechanisms are described in a cell type and disease stage-specific context, and the roles of environmental and lifestyle factors in remodeling the cardiovascular epigenome are illustrated. Novel epigenetic biomarkers and therapeutic interventions are also assessed. Emphasis is placed on epigenomic plasticity, enhancer focused control, and network-level reprogramming as key concepts that drive disease remodeling. By unifying mechanistic understanding with translational evidence, this review frames CVD as a disorder of stabilized regulatory states and defines avenues for precision epigenomic manipulation.