文献类型：期刊文献

英文题名：Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population

作者：Lin, Ao[1];Mao, Chun[1];Rao, Boqi[1];Zhao, Hongjun[2];Wang, Yunchao[3];Yang, Guokang[3];Lei, Haisheng[3];Xie, Chenli[4];Huang, Dongsheng[5];Deng, Yibin[6];Zhang, Xuhui[7];Wang, Xinhua[3];Lu, Jiachun[1]

第一作者：Lin, Ao

通信作者：Lu, JC[1];Wang, XH[2]

机构：[1]Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China;[2]Wenzhou Med Univ, Quzhou Peoples Hosp, Dept Pulm & Crit Care Med, Quzhou Affiliated Hosp, Quzhou, Peoples R China;[3]Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou, Peoples R China;[4]Dongguan Binwan Cent Hosp, Dept Resp & Crit Care Med, Dongguan, Peoples R China;[5]Shenzhen Longhua Dist Cent Hosp, Dept Resp & Crit Care Med, Shenzhen, Peoples R China;[6]Youjiang Med Univ Nationalities, Affiliated Hosp, Ctr Med Lab Sci, Baise, Peoples R China;[7]Gansu Univ Chinese Med, Dept Resp Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China

通信机构：[1]corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：11

外文期刊名：FRONTIERS IN PUBLIC HEALTH

收录：;Scopus(收录号：2-s2.0-85150446198);WOS:【SSCI(收录号:WOS:000949172200001)，SCI-EXPANDED(收录号:WOS:000949172200001)】；

基金：Funding This study was supported by the following grants: National Natural Science Foundation of China 82173609, 81872694, and 81673267 (JL), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program 2017BT01S155 (JL), the Science and Technology Project of Guangzhou 202103000073 (JL), National Key Research and Development Project of China 2017YFC0907202 (XW), National Natural Science Foundation of China 81460123 (YD), Guangxi Natural Foundation 2018GXNSFAA281187 (YD), and National Natural Science Foundation of China 82260889 (XZ).

语种：英文

外文关键词：COPD; altitude; prevalence; risk factor; nomogram

摘要：BackgroundChronic Obstructive Pulmonary Disease (COPD) is a common and harmful disease that requires an effective tool to early screen high-risk individuals. Gansu has unique environments and customs, leading to the different prevalence and etiology of COPD from other regions. The association between altitude and COPD once attracted epidemiologists' attention. However, the prevalence in Gansu and the role of altitude are still unclarified. MethodsIn Gansu, a multistage stratified cluster sampling procedure was utilized to select a representative sample aged 40 years or older. The questionnaire and spirometry examination were implemented to collect participants' information. The diagnosis and assessment of COPD were identified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion, while post-bronchodilator FEV1/FVC < LLN was for sensitivity analysis. Furthermore, the effect of high altitude on COPD was evaluated by the logistic regression model after propensity score matching (PSM). Finally, the participants were randomly divided into training and validation sets. The training set was used to screen the relative factors and construct a nomogram which was further assessed by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) in the two sets. ResultsThere were 2,486 eligible participants in the final analysis, of which 1,584 lived in low altitudes and 902 lived in high altitudes. Based on the GOLD criterion, the crude and standardized prevalences in Gansu were 20.4% (18.7-22.0) and 19.7% (17.9-21.6). After PSM, the logistic regression model indicated that high altitude increased COPD risk [PSM OR: 1.516 (1.162-1.978)]. Altitude, age, sex, history of tuberculosis, coal as fuel, and smoking status were reserved for developing a nomogram that demonstrated excellent discrimination, calibration, and clinical benefit in the two sets. ConclusionsCOPD has become a serious public health problem in Gansu. High altitude is a risk factor for COPD. The nomogram has satisfactory efficiency in screening high-risk individuals.