文献类型：期刊文献

英文题名：High-performance electrochemical biosensor for nonenzymatic H2O2 sensing based on Au@C-Co3O4 heterostructures

作者：Dai, Hongxia[1,2,4]; Chen, Yonglei[1,2]; Niu, Xiaoying[1,2]; Pan, Congjie[1,2]; Chen, HongLi[1,2]; Chen, Xingguo[1,2,3]

第一作者：Dai, Hongxia;戴红霞

通信作者：Chen, Yonglei

机构：[1] State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China; [2] Department of Chemistry, Lanzhou University, Lanzhou, 730000, China; [3] Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou, 730000, China; [4] Gansu University of Chinese Medicine, Lanzhou, 730000, China

第一机构：State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China

通信机构：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China

年份：2018

卷号：118

起止页码：36

外文期刊名：Biosensors and Bioelectronics

收录：EI(收录号：20183005603573);Scopus(收录号：2-s2.0-85050334918)

语种：英文

外文关键词：Biosensors - Electrochemical biosensors - Gold compounds - Transition metal oxides

摘要：An ingenious and viable method for preparing heterogeneous Co3O4 dodecahedrons that contain carbon and encapsulated Au nanoparticles (Au@C-Co3O4) was proposed via pyrolysis of Au nanoparticle-encapsulated zeolitic imidazolate framework-67 (Au@ZIF-67). The obtained Au@C-Co3O4 possessed hierarchically porous structure, abundant active sites, excellent conductivity, and durability, all of which can significantly improve the analysis performance of the biosensor. Meanwhile, the fabricated electrode based on the porous Au@C-Co3O4 showed remarkable electrocatalytic performance towards H2O2 with a limit of detection of 19 nM and ultra-high sensitivity of 7553 μA mM?1 cm?2, even when the Au content in the composite was as low as 0.85 wt%. This novel biosensor was successfully used to monitor H2O2 concentration released from living cells, and the results can be used to identify cancer cells, thus advancing the use of transition metal oxides in the field of biosensing. ? 2018 Elsevier B.V.