文献类型：期刊文献

英文题名：Protective effect of dexmedetomidine combined with remifentanil on perioperative brain tissue in patients with severe traumatic brain injury and its influence on serum inflammatory markers

作者：Luo, Taotao;Zhang, Xuezhi;Luo, Yating;He, Boqi;Xie, Yongle[1]

第一作者：罗婷婷

通信作者：Xie, YL[1]

机构：[1]Gansu Univ Chinese Med, 35 Dingxi East Rd, Lanzhou 200031, Gansu, Peoples R China; Tianshui First Peoples Hosp, Tianshui, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, 35 Dingxi East Rd, Lanzhou 200031, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：82

期号：6

起止页码：325

外文期刊名：VOJNOSANITETSKI PREGLED

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001533406500001)】；

语种：英文

外文关键词：analgesia; brain; craniocerebral trauma; deep sedation; dexmedetomidine; quality of life; remifentanil; treatment outcome

摘要：Background/Aim. Patients with a severe traumatic brain injury (TBI) demand intensive monitoring and treatment due to significant brain trauma or other accompanying causes, such as comorbidities or polytrauma. Patients with such injuries are under intense stress, leading to increased sympathetic excitability, and often experience agitation and pain. Appropriate sedation and analgesia are crucial for these patients, as they can reduce complications, mortality, and sequelae and improve quality of life. The aim of this study was to examine the impact of dexmedetomidine combined with remifentanil on postoperative sedation, analgesia, and cerebral oxygen metabolism in patients with TBI. Methods. A prospective, single-blind, randomized, controlled clinical study included 80 patients divided into two groups: a control group (CG) that received dexmedetomidine (n = 40) and an observation group (OG) that received dexmedetomidine combined with remifentanil (n = 40).Results. Compared to CG, OG demonstrated superior sedation and analgesia, reduced sedation and mechanical ventilation durations, and lower heart rate, mean arterial pressure, and respiratory rate. Additionally, OG showed statistically greater reductions in inflammatory markers and serum cortisol levels and higher 6-endorphin levels. Cerebral oxygen metabolism indices also improved more in the OG postoperatively, although the differences were not statistically significant. Conclusion. Sedation and pain management strategy using of dexmedetomidine combined with remifentanil improved patient outcomes by speeding recovery and reducing physiological stress. Additional research is needed to determine the long-term effects of this combination on brain oxygen metabolism.