文献类型：期刊文献

英文题名：Progress in the study of mefloquine as an antibiotic adjuvant for combination bacterial inhibition treatment

作者：Liang, Xiaofang[1,2];Liu, Zhihong[1,2];Wang, Yulin[2,3];Zhang, Yu[1,2];Deng, Wenbo[1,2];Liu, Qianqian[2];Lu, Zhangping[2];Li, Keke[2];Chang, Yanbing[2];Wei, Lianhua[1,2]

第一作者：Liang, Xiaofang

通信作者：Wei, LH[1];Wei, LH[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[3]Ningxia Med Univ, Yinchuan, Ningxia, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2024

卷号：14

外文期刊名：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85211596375);WOS:【SCI-EXPANDED(收录号:WOS:001374826400001)】；

基金：The support of School of Public Health, Gansu University of Chinese Medicine is gratefully acknowledged. Thanks for the provision and support of laboratory facilities and equipment in the Laboratory of Gansu Provincial People's Hospital.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The author(s) declare financial support was received for the authorship, and/or publication of this article. The authors extend their appreciation to the Gansu Provincial People's Hospital Subject 21GSSYC-44.

语种：英文

外文关键词：mefloquine; antibiotic adjuvant; multidrug-resistant bacteria; derivatives; bacterial cell membrane; biofilm

摘要：Antimicrobial resistance is among the greatest threats to public health globally, and drug repurposing strategies may be advantageous to addressing this problem. Mefloquine, a drug traditionally used to treat malaria, has emerged as a promising antibiotic adjuvant, due to its ability to enhance the effectiveness of conventional antibiotics against resistant bacterial strains. In this paper, we first outline the enhancement properties of mefloquine and its mechanisms of action as an adjuvant antibiotic against multidrug-resistant bacteria. Mefloquine exhibits synergistic bacteriostatic effects when combined with colistin, beta-lactams, antituberculosis drugs, quinolones, and linezolid. Potential mechanisms underlying its synergistic effects include inhibition of antibiotic efflux, disruption of bacterial cell membrane integrity, and disturbance of biofilm formation. In addition, we explore the bacteriostatic effects of several mefloquine derivatives against Mycobacterium tuberculosis and some fungi. Further, we summarize the findings of recent studies on other aspects of mefloquine activity, including its antiviral and antitumor effects. Finally, the advantages and challenges of mefloquine use as an antibiotic adjuvant in combination with antibiotics for bacterial inhibition are discussed. Overall, mefloquine shows excellent potential as an antibiotic adjuvant therapy against multidrug-resistant bacteria and is a promising candidate for combination therapy; however, further studies are needed to fully elucidate its mechanism of action and address the challenges associated with its clinical application.