文献类型：期刊文献

英文题名：Effects of salt substitute on home blood pressure differs according to age and degree of blood pressure in hypertensive patients and their families

作者：Hu, Jihong[1,2,3,5];Zhao, Liancheng[1,2,3];Thompson, Brian[6];Zhang, Yawei[6,7];Wu, Yangfeng[1,2,3,4]

第一作者：Hu, Jihong;胡继宏

通信作者：Wu, YF[1]

机构：[1]Chinese Acad Med Sci, Cardiovasc Inst, Dept Epidemiol, Beijing, Peoples R China;[2]Chinese Acad Med Sci, Fuwai Hosp, Beijing, Peoples R China;[3]Peking Union Med Coll, Beijing, Peoples R China;[4]Peking Univ, Publ Hlth Sch, Dept Epidemiol, Hlth Sci Ctr, Beijing, Peoples R China;[5]Gansu Univ Chinese Med, Publ Hlth Sch, Lanzhou, Gansu, Peoples R China;[6]Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA;[7]Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA

第一机构：Chinese Acad Med Sci, Cardiovasc Inst, Dept Epidemiol, Beijing, Peoples R China

通信机构：[1]corresponding author), Peking Univ, Sch Publ Hlth, 38 Xueyuanlu, Beijing 100083, Peoples R China.

年份：2018

卷号：40

期号：7

起止页码：664

外文期刊名：CLINICAL AND EXPERIMENTAL HYPERTENSION

收录：;Scopus(收录号：2-s2.0-85041558700);WOS:【SCI-EXPANDED(收录号:WOS:000443853300011)】；

基金：This work was supported by the Danone Nutrition Fund in People's Republic of China. Local principal investigators of this study were as follows: Beijing, The Community Health Service Center of Yinghai, Daxing District: Qi Jianhua, Pan Rujun, The Community Health Service Center of Taihe, Daxing District: Chen Baojun, Pan Zhentang.

语种：英文

外文关键词：Salt substitute; family members; home blood pressure; sodium; potassium

摘要：Background: It is known that home blood pressure (HBP) is a more reliable assessment of hypertension treatments than clinical blood pressure (BP). Despite this, HBP response to a salt substitute has only been evaluated by one study which, did not look at the salt substitute's effect on family members and did not analyze by age, gender, or BP degree. The aim of this current study was to assess the effects of a low-sodium and high-potassium salt substitute on HBP among hypertensive patients and their family members. Methods: A total of 220 households (including 220 hypertensive patients and 380 their families) were randomly assigned to the regular salt or salt substitute groups. HBP was measured at the beginning, 3rd, 6th, and 12th months. Among the patients (n = 220), only home systolic blood pressure (HSBP) was significantly reduced, by an adjusted baseline BP of 4.2 mm Hg (95% CI: 1.3-7.0 mm Hg), in the salt substitute group compared with those in the regular salt group at each visit (all P < 0.05). There were no detectable differences between groups for home diastolic blood pressure (HDBP) at any visit. Among the family members, HSBP and HDBP were not significantly different between the groups. Furthermore, Individuals 60 years old, hypertensive patients with stage-2 hypertension, family members with hypertension, and women experienced greater HSBP reduction. Conclusions: Older subjects, those with higher blood pressure, and women experienced greater home blood pressure reduction from the salt substitute compared to regular salt.