文献类型：期刊文献

中文题名：基于脑-肠轴理论浅析中西医防治溃疡性结肠炎

英文题名：Analysis on Prevention and Treatment of UC by Traditional Chinese and Western Medicine Based on Brain-Gut Axis Theory

作者：苏海霞[1];付兆媛[2];高永泽[1];尉戎戎[1];钟建春[1]

第一作者：苏海霞

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：39

期号：9

起止页码：43

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：甘肃省兰州市城关区课题(2021JSCX0008);甘肃中医药大学附属医院院内基金(gzfy-2020-11);甘肃省中西医结合肿瘤临床医学研究中心开放基金项目(zlzx2021-4)。

语种：中文

中文关键词：脑-肠轴;溃疡性结肠炎;压力应激;脑肠同调

外文关键词：Brain-gut axis;Ulcerative colitis;Stress stimulation;Brain-gut homology

摘要：溃疡性结肠炎发病率高、病因复杂且经久不愈。近年来脑-肠同调在肠病诊疗中的作用不断突显,通过综述脑-肠轴理论、脑-肠轴与溃疡性结肠炎发病、脑肠同调等方面的内容,发现脑-肠同调治疗能够遵循疏肝健脾温肾及心理疏导等理念,多靶点干预神明之枢失衡与胃肠腑气不通所致的消化道不适与精神心理症状。因此,笔者认为以脑-肠轴系统为基础,从肝、脾、肾三脏入手,通过调节连接肠道和大脑的与应激或应激介质对沿脑-肠轴的正常和病理胃肠功能的影响有关的传入和传出通路,调节脑肠肽水平、改善脑-肠互动、结合患者心理辅导及中医调畅情志等手段或将成为未来中西医结合治疗溃疡性结肠炎的新角度和新方法。
Ulcerative colitis(UC)has the characteristic of high morbidity,complicated etiology and prolonged course.The role of brain-gut homology is becoming predominant in the diagnosis and treatment of intestinal diseases in recent years.It is found that brain-gut homology therapy can follow the ideas of soothing Liver,invigorating Spleen,warming Kidney and psychological counselling to intervene discomfort of digestive tract and mental symptoms due to imbalance of Shen pivot and Qi obstruction of Stomach and Intestines,by reviewing brain-gut axis theory,the association of brain-gut axis and UC,as well as brain-gut homology.Therefore,the authors suggest that based on brain-gut axis,the afferent and efferent pathways related to effects of stress or stress media on normal and pathological gastrointestinal function connected with gut and brain can be regulated by regulating the three organs,namely Liver,Spleen and Kidney.Regulating level of brain-gut peptide,improving brain-gut interaction,combining psychological counseling and TCM regulating emotions may become a new perspective and method for the treatment of UC in the future.