文献类型：期刊文献

中文题名：姬松茸活性物质抗肿瘤作用研究进展

英文题名：Research Advances in Antitumor Bioactive Compounds from Agaricus Blazei Murrill

作者：王彩霞[1];范俊顺[1];刘仕卿[1];刘露[1];孙延庆[1,2]

第一作者：王彩霞

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省人民医院,兰州730000

第一机构：甘肃中医药大学

年份：2026

卷号：43

期号：2

起止页码：340

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：;北大核心:【北大核心2023】；

基金：甘肃省卫生健康科研计划项目(GSWSHL2021-026);甘肃省人民医院院内项目(23GSSYD-23)。

语种：中文

中文关键词：姬松茸;活性物质;抗肿瘤机制;免疫调节;协同化疗

外文关键词：Agaricus blazei Murill;bioactive compounds;antitumor mechanisms;immunomodulation;chemosensitization

摘要：在肿瘤治疗研究领域,姬松茸(Agaricus blazei Murrill,ABM)作为一种药食同源的珍贵食用菌,其抗肿瘤特性备受关注,但目前尚缺乏对ABM抗肿瘤机制的系统性总结。现有研究表明,ABM的活性成分能够通过多靶点、多通路的协同作用实现抗肿瘤效应,包括诱导肿瘤细胞凋亡、阻滞细胞周期、抑制肿瘤血管生成及调节肿瘤免疫微环境等。在临床应用方面,ABM通过与化疗药物协同作用,逆转肿瘤细胞的多药耐药性(multiple drug resistance,MDR),减轻放化疗不良反应,提高患者免疫功能及生活质量。然而,ABM研究仍存在一些挑战,包括活性成分的机制不清,生物利用度低,临床试验数据相对不足等问题,未来可结合纳米载体技术优化给药策略,开展高质量临床试验验证其安全性及有效性。本文全面深入地对ABM所含多糖、甾醇、萜类以及多酚等活性物质的抗肿瘤机制进行系统梳理与综述,并对临床研究现状进行剖析,期望为ABM在肿瘤治疗领域的深入研究和临床应用提供有价值的理论依据和参考。
In the field of tumor therapy research,Agaricus blazei Murrill(ABM),a valuable edible mushroom with both nutritional and medicinal properties,has attracted significant attention for its antitumor potential.To date,a comprehensive systematic review of its antitumor mechanisms remains lacking.Studies indicate that active compounds in ABM exert antitumor effects through multi-target and multi-pathway synergistic mechanisms,including inducing tumor cell apoptosis,arresting the cell cycle,suppressing tumor angiogenesis,and modulating the tumor immune microenvironment.Clinically,ABM extracts synergize with chemotherapeutic agents to reverse tumor cell multidrug resistance,alleviate adverse effects of radiotherapy and chemotherapy,and enhance immune function and quality of life in patients.However,challenges persist,such as unclear mechanisms of action of active components,limited clinical data,and low bioavailability.Future research could integrate nanocarrier technology to optimize drug delivery strategies and conduct high-quality clinical trials to validate its safety and efficacy.This review aimed to systematically synthesize current knowledge on the antitumor mechanisms of ABM-derived bioactive compounds,including polysaccharides,sterols,terpenoids,and polyphenols,and critically analyze clinical research progress.By providing a robust theoretical foundation and actionable insights,this work seeks to advance the translational potential of ABM in oncology.