详细信息
当归不同炮制饮片“性-效-物”差异性分析
Analysis on the Differences of Medicinal Properties-efficacy-quality Markers of Different Decoction Pieces of Angelica Sinensis
文献类型:期刊文献
中文题名:当归不同炮制饮片“性-效-物”差异性分析
英文题名:Analysis on the Differences of Medicinal Properties-efficacy-quality Markers of Different Decoction Pieces of Angelica Sinensis
作者:石玉存[1,2];尹凯[1,2];高帆[1,2];杜丽东[1,2,3];王瑞琼[1,2,4,5];吴国泰[2,3,4,5]
第一作者:石玉存
机构:[1]甘肃中医药大学药学院,兰州730000;[2]陇药产业创新研究院,兰州730000;[3]甘肃省中药药理与毒理学重点实验室,兰州730000;[4]西北中藏药省部共建协同创新中心,兰州730000;[5]国家中药炮制技术传承基地,兰州730000
第一机构:甘肃中医药大学药学院(西北中藏药协同创新中心办公室)
年份:2025
卷号:42
期号:18
起止页码:3259
中文期刊名:中国现代应用药学
外文期刊名:Chinese Journal of Modern Applied Pharmacy
收录:;北大核心:【北大核心2023】;
基金:国家自然科学基金项目(82260772);甘肃省重点人才团队基金资助项目(2019-39);甘肃省自然科学基金项目(21JR11RA137);甘肃省药品监督管理局科研项目(2023GSMPA026)。
语种:中文
中文关键词:当归饮片;药性;药效;质量标志物
外文关键词:Angelica sinensis decoction pieces;medicinal properties;curative effect;quality markers
摘要:当归临床常用的炮制饮片有4种,即生当归、酒当归、土炒当归和当归炭。不同当归炮制饮片的药性、药效和主要药效成分存在一定的差异。现代研究多基于“成分-药效”的二元变化模式,揭示了当归不同炮制饮片主要药效的差异和药效物质基础的变化特点,但对炮制存性或炮制改性的研究较少。本文结合现有的研究结果,从药性、药效、物质基础3个方面分析了当归不同炮制饮片的质量属性,探讨“性-效-物”的变化规律,为当归的炮制理论提供证据支持。
The 4 kinds of processed decoction pieces commonly used in the clinical practice of Angelica sinensis were raw A.Sinensis,wine-processed A.Sinensis,soil-stir-baked A.sinensis and A.Sinensis carbonisata.There are certain differences in the medicinal properties,efficacy and main pharmacodynamic components of different decoction pieces of A.sinensis.New research is mostly based on the binary change mode of“ingredient-efficacy”,revealing the differences in the main pharmacodynamics of different processed decoction pieces of A.sinensis and the change rule of the material basis of pharmacodynamics,but there are few explorations of processing properties or processing modifications.This paper analyzes the quality attributes of different decoction pieces of A.sinensis from drug properties,efficacy,and material basis of curative effect,and the depth discussion of transmission change rule“medicinal properties-efficacy-quality markers”is completed,so as to provide evidence support for the processing theory of A.sinensis.
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