文献类型：期刊文献

英文题名：Pharmacological action of Hedysarum polysaccharides: a review

作者：Gao, Xiang[1,2,3,4];Ren, Chunzhen[1,2,3];Li, Linyu[2,3,5];Zhao, Huilin[1,2,3];Liu, Kai[1,2,3];Zhuang, Mengjie[6];Lv, Xinfang[1,2,3,4];Zhi, Xiaodong[1,2,3,4];Jiang, Hugang[1,2,3];Chen, Qilin[1,2,3];Zhao, Xinke[1,2,3,4];Li, Yingdong[1,2,3]

第一作者：Gao, Xiang;高翔

通信作者：Zhao, XK[1];Li, YD[1];Zhao, XK[2];Li, YD[2];Zhao, XK[3];Li, YD[3];Zhao, XK[4]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[3]Key Clin Specialty Natl Hlth Commiss Peoples Repub, Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[6]Xinjiang Med Univ, Sch Basic Med, Urumqi, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[3]corresponding author), Key Clin Specialty Natl Hlth Commiss Peoples Repub, Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001070127100001)】；

基金：This is work was supported by the 2021 Jiaoyu Jiebang Guashuai Project (No. 2021 jyjbgs-03), 2022 Gansu Province Longyuan Youth Innovation and Entrepreneurship Talent Project, 2022 Gansu Province outstanding graduate student "Chuangxin Zhi xing" project (NO. 2022CXZX-736), 2022 Gansu Province natural sciences fund (22JR11RA128) and National Natural Science Foundation of China (NO. 82260869), National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Support Project.

语种：英文

外文关键词：HPS; anti-inflammatory; complications of diabetes; anti-tumor; traditional Chinese medicine

摘要：Hedysarum, a traditional Chinese herbal medicine and food with a long history of clinical application, is used to improve health conditions and treat various diseases. Hedysarum polysaccharides (HPS), flavonoids, saponins, and alkaloids, are the primary components of Hedysarum. HPS is the most important natural active ingredient of Hedysarum, which has many pharmacological effects. Currently, HPS exhibits significant promise in drug development for various ailments such as tumors, diabetes, cardiovascular diseases, Alzheimer's disease, and fibrosis. This review paper discusses the extraction, separation, and content determination techniques of HPS, along with the investigation of its chemical constituents. More importantly, we reviewed the anti-inflammatory pharmacological effects of HPS, such as inhibition of inflammatory factors and NF-?B signaling pathway; antitumor activity through apoptosis induction in tumor cells and blocking tumor cell proliferation and metastasis; antioxidant effects; regulation of various cytokines and immune cells; regulation of blood sugar levels, such as in type I and type II diabetes and in diabetic complications; improvement in symptoms of Alzheimer disease; anti-aging and anti-fibrosis properties; and improvement in cerebral ischemia-reperfusion injury. This review paper establishes the theoretical foundation for future studies on the structure, mechanism, and clinical use of HPS.