文献类型：期刊文献

英文题名：YBX1: A Multifunctional Protein in Senescence and Immune Regulation

作者：Zhang, Wenze[1];Liu, Ying[2];Zhao, Zhe[2];Zhang, Yizhi[2];Liang, Yujuan[2];Wang, Wanxia[1,3]

第一作者：Zhang, Wenze

通信作者：Wang, WX[1];Wang, WX[2]

机构：[1]Lanzhou Univ, Coll Clin Med 1, Lanzhou 730000, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[3]NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Coll Clin Med 1, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Clin Med 1, Lanzhou 730000, Peoples R China;[2]corresponding author), NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China.

年份：2024

卷号：46

期号：12

起止页码：14058

外文期刊名：CURRENT ISSUES IN MOLECULAR BIOLOGY

收录：;Scopus(收录号：2-s2.0-85213481197);WOS:【SCI-EXPANDED(收录号:WOS:001383775700001)】；

基金：This work was supported by the Gansu Provincial Health Industry Project (GSMSQN2021-004) and the Gansu Provincial Hospital In-Hospital Fund (23GSSYA-7).

语种：英文

外文关键词：YBX1; cellular senescence; tumor immunity; immunotherapy

摘要：The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas. Initially, YBX1 is shown to be closely associated with cellular senescence and impacts significant biological processes, including cell proliferation, damage repair, and metabolism. This suggests potential applications in the prevention and treatment of senescence-related diseases. Additionally, YBX1 regulates the immune response by controlling the function of immune cells and the expression of immune molecules. It is essential in maintaining immune system homeostasis and impacts the pathological process of various diseases, including tumors. Lastly, the diverse functions of the YBX1 protein make it a promising candidate for the development of innovative therapeutic strategies for diseases. Comprehensive research on its mechanisms could provide novel insights and approaches for the prevention, diagnosis, and treatment of related diseases.