文献类型：期刊文献

中文题名：不同来源黄芩炮制品的解热作用比较研究

英文题名：Comparitive Study on Antipyretic Effects of Processed Products of Scutellariae Radix from Different Origins

作者：杨志军[1];杨秀娟[1];张金保[1];耿广琴[1];杜弢[1,2]

第一作者：杨志军

机构：[1]甘肃中医药大学;[2]甘肃中医药大学药用植物遗传育种研究所

第一机构：甘肃中医药大学

年份：2017

卷号：34

期号：1

起止页码：16

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

基金：甘肃省高校基本科研业务费项目(BH2012-020);甘肃省中药材产业科技攻关项目(GYC12-05)

语种：中文

中文关键词：黄芩;来源;炮制;解热

外文关键词：Scutellaria baicalensis; origins; processing; antipyretic effect

摘要：目的比较二倍体黄芩、四倍体黄芩、甘肃黄芩的解热作用。方法将Wistar大鼠110只,随机分为11组。药物组分别给予不同来源的黄芩生品、酒炙品水煎液灌胃,连续给药2 d。第3天,除空白组外,其余各组大鼠腹腔注射脂多糖100μg·kg^(-1)造模。2 h后,继续灌胃1次。造模1,2,3,4 h分别检测大鼠肛温,动物处死后采血,检测大鼠血清中IL^(-1)β、PGE2含量。结果与模型组比较,黄芩各药物组大鼠在造模2,3,4 h时ΔT显著低于模型组,且大鼠血清中IL^(-1)β、PGE2含量显著降低(P<0.05);与道地产区河北产黄芩组比较,甘肃黄芩Ⅰ组(生品)、Ⅱ组(酒炙品)大鼠2,3,4 h时ΔT均显著高于河北产黄芩组(P<0.05);同时,二倍体黄芩、四倍体黄芩、甘肃黄芩的Ⅰ组(生品)、Ⅱ组(酒炙品)大鼠血清中IL^(-1)β、PGE2含量均显著高于河北产黄芩Ⅰ组、Ⅱ组(P<0.05)。结论二倍体黄芩、四倍体黄芩、甘肃黄芩均有解热作用,但甘肃黄芩解热作用与道地黄芩有一定差异。不同来源黄芩生品与酒炙品对发热大鼠的解热作用无显著性影响。
OBJECTIVE To compare antipyretic effects of the root of tetraploid, diploid Scutellaria baicalensis and Scutellaria rehderiana cultivated in Gansu. METHODS The 110 Wistar rats were randomly divided into 11 groups. Drug intervention groups were given corresponding drugs for 2 d. On the third day, the rats were given peritoneal injection with 100 μg·kg^-1 lipopolysaccharide to establish model except the blank group. Drugs were given 1 time again 2 h later. The temperature of the rats were detected after 1, 2, 3, 4 h, while the contents of IL^-1β, PGE2 in blood serum were detected after the rats killed. RESULTS Compared with the model group, the change values of the rectal temperature（ΔT） after 2, 3, 4 h and the content of IL^-1β, PGE2 of each drug intervention group were significantly decreased（P〈0.05）. Compared with Hebei Scutellaria baicalensis group, the ΔT of rats in Scutellariae Radix Ⅰ（crude product） and Ⅱ（wine-product） group were remarkably higher（P〈0.05）. In the same time, the content of IL^-1β, PGE2 of rats in Ⅰ（crude product） and Ⅱ（wine-product） group of tetraploid Scutellaria baicalensis, diploid Scutellaria baicalensis and Scutellaria rehderiana cultivated in Gansu were significantly increased（P〈0.05）. CONCLUSION Tetraploid, diploid Scutellaria baicalensis and Scutellaria rehderiana cultivated in Gansu have antipyretic effects, but there is a significant difference between Scutellaria rehderiana and Hebei Scutellaria baicalensis. The antipyretic effects of Scutellaria baicalensis have no significant difference between crude product and wine-product.