文献类型：期刊文献

中文题名：组学技术在中药防治子宫内膜异位症中的研究现状

英文题名：Research status of histological techniques in traditional Chinese medicine for prevention and treatment of endometriosis

作者：岳斌[1];褚翠君[1];万文文[1];陈元欢[1];黄灿灿[1];程渊[1];张小花[1];武权生[1];毛海燕[2];梁莉[1]

第一作者：岳斌

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃省人民医院中医科,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：41

期号：5

起止页码：737

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(81760879);国家自然科学基金地区科学基金资助项目(82260949);甘肃省自然科学基金资助项目(23JRRA1751、23JRRA1757);甘肃省中医药科研课题资助项目(GZKP-2023-21);甘肃省人民医院院内科研基金资助项目(23GSSYE-1);甘肃省中医药研究中心开放课题资助项目(zyzx-2023-09);甘肃中医药大学人才引进基金资助项目(301/30140603)。

语种：中文

中文关键词：中药;子宫内膜异位症;多组学技术;作用机制;研究现状

外文关键词：traditional Chinese medicine;endometriosis;multi-omics technology;mechanism of action;research status

摘要：中药防治子宫内膜异位症(EMs)的临床疗效确切,可以通过多途径、多靶点发挥作用。但中药成分的复杂性以及单一的研究方法导致该领域研究进展缓慢。随着高通量技术的出现,通过确定与EMs病理生理学相关的基因,弥补了单个靶点或通路诠释中药“整体调控”的局限性。本综述就基因组学、转录组学、蛋白组学、代谢组学及其联用组学技术揭示中药防治EMs的分子机制等相关研究进行综述,为精准化、客观化揭示防治EMs提供参考思路,同时也为揭示复杂药物干预疾病的机制提供理论依据。
The clinical efficacy of Chinese medicines in the prevention and treatment of endometriosis(EMs)is precise and can work through multiple pathways and targets.However,the complexity of the components of Chinese medicines and the single research method have led to slow progress in this field.With the emergence of high-throughput technologies,the limitations of single targets or pathways in interpreting the"holistic regulation"of TCM have been remedied by identifying genes associated with the pathophysiology of endometriosis.In this review,genomics,transcriptomics,proteomics,metabolomics,and their combinatorial techniques are reviewed to reveal the molecular mechanisms of Chinese herbal medicines in the prevention and treatment of endometriosis.It provides reference ideas for precise and objective revelation of prevention and treatment of EMs,as well as theoretical basis for revealing the mechanism of complex drug intervention in the disease.