文献类型：期刊文献

英文题名：Micronutrients and skin cancer risk: a Mendelian randomization study

作者：Chen, Wangcheng[1,2];Pang, Lili[1,3];Wei, Xiuzhen[1,3];Lan, Yuemei[1,3];Su, Xiayi[1,2];Dong, Yaling[1,3];Zhu, Zhibo[1,3];Bai, Jie[3];Zhou, Jiayan[2];Cui, Heteng[1];Zhang, Baihong[1]

第一作者：Chen, Wangcheng

通信作者：Cui, HT[1];Zhang, BH[1]

机构：[1]940Th Hosp Joint Logist Support Force Chinese Peop, Dept Oncol, Lanzhou 730050, Peoples R China;[2]Northwest Minzu Univ, Coll Med, Oncol, Lanzhou 730050, Peoples R China;[3]Gansu Univ Chinese Med, Sch Clin Med 1, Oncol, Lanzhou 730000, Peoples R China

第一机构：940Th Hosp Joint Logist Support Force Chinese Peop, Dept Oncol, Lanzhou 730050, Peoples R China

通信机构：[1]corresponding author), 940Th Hosp Joint Logist Support Force Chinese Peop, Dept Oncol, Lanzhou 730050, Peoples R China.

年份：2025

卷号：23

期号：1

外文期刊名：WORLD JOURNAL OF SURGICAL ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105004675632);WOS:【SCI-EXPANDED(收录号:WOS:001488652300002)】；

基金：Natural Science Foundation of Gansu Province of China (No. 22JR5RA007). In-house project the 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army (No.2021yxky052).

语种：英文

外文关键词：Mendelian Randomization; Skin cancer; Micronutrients; Non-melanoma skin cancer; Malignant melanoma

摘要：Background The intake of micronutrients is linked to cancer risk, but their specific mechanisms in skin cancer remain unclear. This study systematically investigated the causal effects of 15 micronutrients on non-melanoma skin cancer (NMSC) and malignant melanoma (MM) using Mendelian Randomization (MR). Methods Genetically predicted levels of 15 micronutrients served as instrumental variables in a two-sample MR analysis, utilizing data from the Finnish FinnGen database (version R10). To address potential horizontal pleiotropy and heterogeneity, sensitivity analyses included inverse-variance weighted (IVW), weighted median, MR Egger regression, and MR PRESSO. The study analyzed data from 650,657 European participants, including 19,077 NMSC and 3,194 MM cases. Results Selenium (p = 0.0001, OR 0.788, 95% CI 0.703-0.883) and Potassium (p = 0.045, OR 0.463, 95% CI 0.219-0.982) were significantly negatively associated with MM risk, suggesting a protective effect. Conversely, Calcium (p = 0.025, OR 1.257, 95% CI 1.030-1.534) was positively associated with NMSC risk, indicating it may be a risk factor. Vitamin B6 (p = 0.004, OR 0.741, 95% CI 0.604-0.909) also showed a significant protective effect against NMSC.The remaining 11 micronutrients showed no significant causal association with NMSC or MM (p > 0.05). Conclusions This study highlights that Selenium and Potassium may protect against MM, while Calcium increases NMSC risk, with Vitamin B6 providing protection against NMSC. These findings enhance our understanding of micronutrients in skin cancer mechanisms and inform potential prevention strategies.